β-Carboline-1-carboxylic acid

製品番号: HY-29268: Data Sheet 取扱説明書
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β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC₅₀: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC₅₀: 47.70 μg/mL) and E. coli (IC₅₀: 19.17 μg/mL).

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β-Carboline-1-carboxylic acid 構造式

CAS 番号 : 26052-96-0

容量	価格（税別）	在庫状況	数量
1 mg	$670	お問い合わせ 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	$2011	お問い合わせ 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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Indoleamine 2,3-Dioxygenase (IDO) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IDO1 IDO2 IDO

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明	β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC₅₀: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC₅₀: 47.70 μg/mL) and E. coli (IC₅₀: 19.17 μg/mL)^[1]^[2]^[3]^[4].
分子量	212.20
分子式	C₁₂H₈N₂O₂
CAS 番号	26052-96-0
SMILES	O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	データシート (275 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Cui Y, et al. β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. J Ethnopharmacol. 2019 Oct 28;243:112096. [Content Brief] [2]. Sung Y, et al. Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related beta-carboline alkaloids. Chem Pharm Bull (Tokyo). 1984 May;32(5):1872-7. [Content Brief] [3]. Wang N, et al. Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. Fitoterapia. 2019 Mar;133:137-145. [Content Brief] [4]. Hu H, et al. Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides' Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation. Front Pharmacol. 2021 Oct 27;12:761751. [Content Brief]