26052-96-0
Chemical Structure
β-Carboline-1-carboxylic acid
- CAS No.: 26052-96-0
- Formula:C12H8N2O2
- Molecular Weight:212.20
InChIKey: VNPNEGORDFERGK-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O
Biological Activity: β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL)[1][2][3][4].
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β-Carboline-1-carboxylic acid | β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL). | |||||||||||||||||||||
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References
- [1]. Cui Y, et al. β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. J Ethnopharmacol. 2019 Oct 28;243:112096. [Content Brief]
- [2]. Sung Y, et al. Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related beta-carboline alkaloids. Chem Pharm Bull (Tokyo). 1984 May;32(5):1872-7. [Content Brief]
- [3]. Wang N, et al. Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. Fitoterapia. 2019 Mar;133:137-145. [Content Brief]
- [4]. Hu H, et al. Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides' Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation. Front Pharmacol. 2021 Oct 27;12:761751. [Content Brief]
