2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP sodium

2',3'-cGAMP sodium  (Synonyms: 2'-3'-cyclic GMP-AMP sodium)

Cat. No.: HY-100564A Purity: 99.57%
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2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.

For research use only. We do not sell to patients.

CAS No. : 2734858-36-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
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10 mM * 1 mL in Water In-stock
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5 mg In-stock
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Customer Review

Based on 33 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP sodium:

2',3'-cGAMP sodium Related Antibodies

Top Publications Citing Use of Products

33 Publications Citing Use of MCE 2',3'-cGAMP sodium

WB
ELISA
Flow Cytometry
In Vivo Efficacy Study

    2',3'-cGAMP sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Western blot assay of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM inducing TBK1, STING, NF-κB and IRF3 phosphorylation in BMDCs in vitro.

    2',3'-cGAMP sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    ELISA assay of IFN-β produced by 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs in vitro.

    2',3'-cGAMP sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Flow cytometric analysis of surface biomarkers for DC maturation, antigen cross-presentation, and LN homing ability of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs.

    2',3'-cGAMP sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Graph presenting tumor volume growth of the B16-OVA tumor-bearing C57BL-6 mice following different treatments over a 16-day period (n = 5). 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days.

    2',3'-cGAMP sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    B16-OVA tumor-bearing C57BL-6 mice were given different treatments over a 16-day period (n = 5), 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days. Illustrative flow cytometric graphs and proportions of T cells in tumor tissues observed on day 7 after the last vaccination.

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    • References

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    Description

    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm[1].

    IC50 & Target

    STING, IFNβ[1]
    In Vitro

    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    2',3'-cGAMP sodium Related Antibodies
    Molecular Weight

    718.37

    Formula

    C20H22N10Na2O13P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1([H])[C@](OP(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)(O[Na])=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O[Na])=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (69.60 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3920 mL 6.9602 mL 13.9204 mL
    5 mM 0.2784 mL 1.3920 mL 2.7841 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 18.33 mg/mL (25.52 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.89%

    SDS (252 KB)

    COA (251 KB) HNMR (248 KB) LCMS (98 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3920 mL 6.9602 mL 13.9204 mL 34.8010 mL
    5 mM 0.2784 mL 1.3920 mL 2.7841 mL 6.9602 mL
    10 mM 0.1392 mL 0.6960 mL 1.3920 mL 3.4801 mL
    15 mM 0.0928 mL 0.4640 mL 0.9280 mL 2.3201 mL
    20 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7401 mL
    25 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
    30 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
    40 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
    50 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
    60 mM 0.0232 mL 0.1160 mL 0.2320 mL 0.5800 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    2',3'-cGAMP sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2',3'-cGAMP2734858-36-52'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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