2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP)

Name: 2',3'-cGAMP
Brand: MedChemExpress
SKU: HY-100564
Rating: 5.0 (33 reviews)

Cat. No.: HY-100564 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 1441190-66-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 33 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP:

2',3'-cGAMP sodium In-stock

33 Publications Citing Use of MCE 2',3'-cGAMP

ELISA

Flow Cytometry

In Vivo Efficacy Study

: 2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]; Western blot assay of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM inducing TBK1, STING, NF-κB and IRF3 phosphorylation in BMDCs in vitro.

: 2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]; ELISA assay of IFN-β produced by 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs in vitro.

: 2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]; Flow cytometric analysis of surface biomarkers for DC maturation, antigen cross-presentation, and LN homing ability of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs.

: 2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]; Graph presenting tumor volume growth of the B16-OVA tumor-bearing C57BL-6 mice following different treatments over a 16-day period (n = 5). 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days.

: 2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365. [Abstract]; B16-OVA tumor-bearing C57BL-6 mice were given different treatments over a 16-day period (n = 5), 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days. Illustrative flow cytometric graphs and proportions of T cells in tumor tissues observed on day 7 after the last vaccination.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

STING, IFNβ^[1]

In Vitro

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

674.41

화학식

C₂₀H₂₄N₁₀O₁₃P₂

CAS No.

1441190-66-4

Appearance

Solid

Color

White to off-white

SMILES

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O

Structure Classification

Others

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : ≥ 50 mg/mL (74.14 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4828 mL	7.4139 mL	14.8278 mL
5 mM	0.2966 mL	1.4828 mL	2.9656 mL
10 mM	0.1483 mL	0.7414 mL	1.4828 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.95%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB) RP-HPLC (204 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4828 mL	7.4139 mL	14.8278 mL	37.0694 mL
	5 mM	0.2966 mL	1.4828 mL	2.9656 mL	7.4139 mL
	10 mM	0.1483 mL	0.7414 mL	1.4828 mL	3.7069 mL
	15 mM	0.0989 mL	0.4943 mL	0.9885 mL	2.4713 mL
	20 mM	0.0741 mL	0.3707 mL	0.7414 mL	1.8535 mL
	25 mM	0.0593 mL	0.2966 mL	0.5931 mL	1.4828 mL
	30 mM	0.0494 mL	0.2471 mL	0.4943 mL	1.2356 mL
	40 mM	0.0371 mL	0.1853 mL	0.3707 mL	0.9267 mL
	50 mM	0.0297 mL	0.1483 mL	0.2966 mL	0.7414 mL
	60 mM	0.0247 mL	0.1236 mL	0.2471 mL	0.6178 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2',3'-cGAMP Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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2',3'-cGAMP (Synonyms: 2'-3'-cyclic GMP-AMP)

고객리뷰

Other Forms of 2',3'-cGAMP:

2',3'-cGAMP Related Antibodies

33 Publications Citing Use of MCE 2',3'-cGAMP

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

2',3'-cGAMP Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

2',3'-cGAMP Related Classifications

Keywords:

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고객리뷰

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SAFETY DATA SHEET (SDS)

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