2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP

2',3'-cGAMP  (Synonyms: 2'-3'-cyclic GMP-AMP)

Cat. No.: HY-100564 Purity: 99.95%
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2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

For research use only. We do not sell to patients.

CAS No. : 1441190-66-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 33 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP:

2',3'-cGAMP Related Antibodies

Top Publications Citing Use of Products

33 Publications Citing Use of MCE 2',3'-cGAMP

WB
ELISA
Flow Cytometry
In Vivo Efficacy Study

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Western blot assay of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM inducing TBK1, STING, NF-κB and IRF3 phosphorylation in BMDCs in vitro.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    ELISA assay of IFN-β produced by 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs in vitro.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Flow cytometric analysis of surface biomarkers for DC maturation, antigen cross-presentation, and LN homing ability of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Graph presenting tumor volume growth of the B16-OVA tumor-bearing C57BL-6 mice following different treatments over a 16-day period (n = 5). 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    B16-OVA tumor-bearing C57BL-6 mice were given different treatments over a 16-day period (n = 5), 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days. Illustrative flow cytometric graphs and proportions of T cells in tumor tissues observed on day 7 after the last vaccination.

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    Description

    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

    IC50 & Target

    STING, IFNβ[1]
    In Vitro

    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    2',3'-cGAMP Related Antibodies
    Molecular Weight

    674.41

    Formula

    C20H24N10O13P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (74.14 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4828 mL 7.4139 mL 14.8278 mL
    5 mM 0.2966 mL 1.4828 mL 2.9656 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (250 KB) RP-HPLC (204 KB) LCMS (103 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4828 mL 7.4139 mL 14.8278 mL 37.0694 mL
    5 mM 0.2966 mL 1.4828 mL 2.9656 mL 7.4139 mL
    10 mM 0.1483 mL 0.7414 mL 1.4828 mL 3.7069 mL
    15 mM 0.0989 mL 0.4943 mL 0.9885 mL 2.4713 mL
    20 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
    25 mM 0.0593 mL 0.2966 mL 0.5931 mL 1.4828 mL
    30 mM 0.0494 mL 0.2471 mL 0.4943 mL 1.2356 mL
    40 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
    50 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7414 mL
    60 mM 0.0247 mL 0.1236 mL 0.2471 mL 0.6178 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    2',3'-cGAMP Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2',3'-cGAMP1441190-66-42'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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