2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endogenous Metabolite STING IFNAR
  4. 2',3'-cGAMP

2',3'-cGAMP  (Synonyms: 2'-3'-cyclic GMP-AMP)

製品番号: HY-100564 純度: 99.95%
COA 取扱説明書 Technical Support

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.

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CAS 番号 : 1441190-66-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 1024 在庫あり
Solution
10 mM * 1 mL in Water USD 1024 在庫あり
Solid
1 mg $300 在庫あり
5 mg $690 在庫あり
10 mg $1250 在庫あり
25 mg $2500 在庫あり
50 mg $4000 在庫あり
100 mg   お問い合わせ  
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カスタマーレビュー

Based on 33 publication(s) in Google Scholar

Other Forms of 2',3'-cGAMP:

2',3'-cGAMP 関連抗体

Top Publications Citing Use of Products

顧客検証

WB
ELISA
Flow Cytometry
In Vivo Efficacy Study

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Western blot assay of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM inducing TBK1, STING, NF-κB and IRF3 phosphorylation in BMDCs in vitro.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    ELISA assay of IFN-β produced by 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs in vitro.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Flow cytometric analysis of surface biomarkers for DC maturation, antigen cross-presentation, and LN homing ability of 2'3'-cGAMP (10 μM, 24 h), and 2'3'-cGAMP-loaded Si9GM in BMDCs.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    Graph presenting tumor volume growth of the B16-OVA tumor-bearing C57BL-6 mice following different treatments over a 16-day period (n = 5). 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days.

    2',3'-cGAMP purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Sep 6:42:345-365.  [Abstract]

    B16-OVA tumor-bearing C57BL-6 mice were given different treatments over a 16-day period (n = 5), 50 μg free 2'3'-cGAMP were vaccinated subcutaneously 4 times at intervals of 3 days. Illustrative flow cytometric graphs and proportions of T cells in tumor tissues observed on day 7 after the last vaccination.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    製品説明

    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

    IC50 & Target

    STING, IFNβ[1]
    体外実験

    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    2',3'-cGAMP 関連抗体
    分子量

    674.41

    分子式

    C20H24N10O13P2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 50 mg/mL (74.14 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4828 mL 7.4139 mL 14.8278 mL
    5 mM 0.2966 mL 1.4828 mL 2.9656 mL
    10 mM 0.1483 mL 0.7414 mL 1.4828 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.95%

    COA (250 KB) RP-HPLC (204 KB) LCMS (103 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4828 mL 7.4139 mL 14.8278 mL 37.0694 mL
    5 mM 0.2966 mL 1.4828 mL 2.9656 mL 7.4139 mL
    10 mM 0.1483 mL 0.7414 mL 1.4828 mL 3.7069 mL
    15 mM 0.0989 mL 0.4943 mL 0.9885 mL 2.4713 mL
    20 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
    25 mM 0.0593 mL 0.2966 mL 0.5931 mL 1.4828 mL
    30 mM 0.0494 mL 0.2471 mL 0.4943 mL 1.2356 mL
    40 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
    50 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7414 mL
    60 mM 0.0247 mL 0.1236 mL 0.2471 mL 0.6178 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    2',3'-cGAMP Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2',3'-cGAMP1441190-66-42'-3'-cyclic GMP-AMPEndogenous MetaboliteSTINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorendogenouscGAMPDNAIFNβInhibitorinhibitorinhibit

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    製品名:
    2',3'-cGAMP
    製品番号:
    HY-100564
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