(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid

製品番号: HY-N8090 純度: 97.84%: Data Sheet SDS COA 取扱説明書
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(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC₅₀ of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities.

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(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid 構造式

CAS 番号 : 1961358-02-0

容量	価格（税別）	在庫状況	数量
1 mg	$150	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

NO Synthase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

nNOS iNOS eNOS

生物活性
純度とドキュメンテーション
参考文献
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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	9.55 μM Compound: 4	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay	[PMID: 27335254]

体外実験

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid shows no significant cytotoxicity on BV-2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

530.65

分子式

C₃₀H₄₂O₈

CAS 番号

1961358-02-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@@]([C@H]1/C(C)=C\C(CC(C)C(O)=O)=O)([C@@H]2O)C)(C(C1)=O)C([C@H](C[C@@]3([H])C4(C)C)O)=C(C2=O)[C@]3(CC[C@@H]4O)C

Structure Classification

Initial Source

Microorganisms

Ganoderma curtisii

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

純度: 97.84%

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データシート (272 KB) SDS (252 KB)

COA (254 KB) HNMR (313 KB) CNMR (315 KB) RP-HPLC (288 KB) MS (120 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Yang Jiao, et al. Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3556-61. [Content Brief]