4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone

Cat. No.: HY-N8184 Pureza: 99.64%: Ficha de datos
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4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity.

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4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone Estructura química

No. CAS : 151752-08-8

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31

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Based on 1 Customer Validation

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•Related Proteins:

Ver todos los productos específicos de isoformas COX:

Ver todas las isoformas

COX COX-1 COX-2 COX-3

Actividad biológica
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Referencias
Revisión del cliente

Descripciòn

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity^[1].

IC₅₀ & Target^[1]

COX-1

COX-2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	42.9 μM Compound: 24	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 19689125]
B16-BL6	IC₅₀	84.4 μM Compound: 24	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 19689125]
HT-1080	IC₅₀	67.2 μM Compound: 24	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19689125]
HeLa	IC₅₀	49 μM Compound: 24	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 19689125]

Peso molecular

302.32

Fòrmula

C₁₇H₁₈O₅

No. CAS

151752-08-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(O)C=C2OC

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (82.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3078 mL	16.5388 mL	33.0775 mL
5 mM	0.6616 mL	3.3078 mL	6.6155 mL
10 mM	0.3308 mL	1.6539 mL	3.3078 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.64%

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Ficha de datos (267 KB) SDS (251 KB)

COA (246 KB) HNMR (145 KB) CNMR (132 KB) RP-HPLC (199 KB) MS (161 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kittisak Likhitwitayawuid, et al. Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri. Planta Med. 2002 Sep;68(9):841-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3078 mL	16.5388 mL	33.0775 mL	82.6938 mL
	5 mM	0.6616 mL	3.3078 mL	6.6155 mL	16.5388 mL
	10 mM	0.3308 mL	1.6539 mL	3.3078 mL	8.2694 mL
	15 mM	0.2205 mL	1.1026 mL	2.2052 mL	5.5129 mL
	20 mM	0.1654 mL	0.8269 mL	1.6539 mL	4.1347 mL
	25 mM	0.1323 mL	0.6616 mL	1.3231 mL	3.3078 mL
	30 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7565 mL
	40 mM	0.0827 mL	0.4135 mL	0.8269 mL	2.0673 mL
	50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6539 mL
	60 mM	0.0551 mL	0.2756 mL	0.5513 mL	1.3782 mL
	80 mM	0.0413 mL	0.2067 mL	0.4135 mL	1.0337 mL