2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Serotonin Transporter
  4. 4-Hydroxy MET

4-Hydroxy MET  (Synonyms: 4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine)

Art. -Nr.: HY-118796 Reinheit: 99.30%
COA
SDS
Handling Instructions Technical Support

4-Hydroxy MET (4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine psychoactive substance. 4-Hydroxy MET is a partial 5-HT2A receptor agonist, a serotonin transporter inhibitor and weak norepinephrine transporter inhibitor. 4-Hydroxy MET affects emotional, motoric, and cognitive functions via serotonergic hallucinogenic activity.

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4-Hydroxy MET

4-Hydroxy MET Chemische Struktur

CAS. Nr. : 77872-41-4

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4-Hydroxy MET Related Antibodies

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Beschreibung

4-Hydroxy MET (4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine psychoactive substance. 4-Hydroxy MET is a partial 5-HT2A receptor agonist, a serotonin transporter inhibitor and weak norepinephrine transporter inhibitor. 4-Hydroxy MET affects emotional, motoric, and cognitive functions via serotonergic hallucinogenic activity[1].

In Vitro

4-Hydroxy MET (5-100 μM; 60-120 min) incubation of pooled human liver microsomes generates 12 distinct phase I metabolites, with mono-hydroxylation, dihydroxylation, demethylation, deethylation, carboxylic acid formation, and N-oxide formation as key biotransformation pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Hydroxy MET Related Antibodies
Molekulargewicht

218.29

Formel

C13H18N2O
CAS. Nr.
Appearance

Solid

Color

White to light blue

SMILES

CN(CCC1=CNC2=C1C(O)=CC=C2)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 100 mg/mL (458.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5811 mL 22.9053 mL 45.8106 mL
5 mM 0.9162 mL 4.5811 mL 9.1621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.30%

SDS (396 KB)

COA (253 KB) HNMR (163 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5811 mL 22.9053 mL 45.8106 mL 114.5266 mL
5 mM 0.9162 mL 4.5811 mL 9.1621 mL 22.9053 mL
10 mM 0.4581 mL 2.2905 mL 4.5811 mL 11.4527 mL
15 mM 0.3054 mL 1.5270 mL 3.0540 mL 7.6351 mL
20 mM 0.2291 mL 1.1453 mL 2.2905 mL 5.7263 mL
25 mM 0.1832 mL 0.9162 mL 1.8324 mL 4.5811 mL
30 mM 0.1527 mL 0.7635 mL 1.5270 mL 3.8176 mL
40 mM 0.1145 mL 0.5726 mL 1.1453 mL 2.8632 mL
50 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2905 mL
60 mM 0.0764 mL 0.3818 mL 0.7635 mL 1.9088 mL
80 mM 0.0573 mL 0.2863 mL 0.5726 mL 1.4316 mL
100 mM 0.0458 mL 0.2291 mL 0.4581 mL 1.1453 mL
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4-Hydroxy MET Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxy MET77872-41-44-HO-MET 4-Hydroxy-N-methyl-N-ethyltryptamine5-HT ReceptorSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A4norepinephrine transporterhuman liver microsomesphase I metabolitesdihydroxylationN-oxide formationdeethylation5-HT2A receptordemethylationserotonin transportermono-hydroxylationInhibitorinhibitorinhibit

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