2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Rilmazafone hydrochloride

Rilmazafone hydrochloride  (Synonyms: 450191S)

Cat. No.: HY-U00228 Purity: 99.57%
COA
SDS
Handling Instructions Technical Support

Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand.

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Rilmazafone hydrochloride

Rilmazafone hydrochloride 화학구조

CAS No. : 85815-37-8

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Other Forms of Rilmazafone hydrochloride:

Rilmazafone hydrochloride Related Antibodies

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제품 설명

Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand[1].

In Vivo

When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S; 200 or 600 mg/kg for 5 or 3 days, respectively) to induce hepatic drug-metabolizing enzymes, plasma concentrations of the metabolites after oral administration of a dose of 200 mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity. Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites, which are almost the same as those in Rilmazafone-pretreatment. On the other hand, administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites, and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats. Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs, which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats. The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

511.79

화학식

C21H21Cl3N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC(NCC1=NC(C(N(C)C)=O)=NN1C2=C(C=C(Cl)C=C2)C(C3=C(C=CC=C3)Cl)=O)=O.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

DMSO : 250 mg/mL (488.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9539 mL 9.7696 mL 19.5393 mL
5 mM 0.3908 mL 1.9539 mL 3.9079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References
Animal Administration
[2]

Mice[2]
Adult male rats of the Jcl Sprague-Dawley strain, 7-8 weeks old, are used for the experiments. The animals are kept in an air-conditioned room (25±1°C, 50-60% humidity) lighted 12 hr a day (8:00-20:00) and maintain on com mercial rat chow and water ad libitum. Rilmazafone is dissolved in 5% (w/v) arabic gum at 20 or 60 mg/mL, and the resulting solution is administered orally to rats at 1.0 mL/100 g body weight for 3-5 days. Typical inducers, phenobarbital (in physiological saline) and beta-naphthoflavone (in sesame oil), are administered intraperitoneally at a dose of 40 mg/kg, once daily for 3 days. The animals are fasted for 24 hr after the last adminis tration of Rilmazafone or inducers, and then the test solution of Rilmazafone (20 mg/mL of 5% arabic gum) is given orally to rats at a dose of 200 mg/kg. Heparinized blood samples are obtained from the abdominal aorta under ether anesthesia and centrifuged immediately to obtain plasma samples using an Eppendorf centrifuge Type 5414S.

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References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9539 mL 9.7696 mL 19.5393 mL 48.8482 mL
5 mM 0.3908 mL 1.9539 mL 3.9079 mL 9.7696 mL
10 mM 0.1954 mL 0.9770 mL 1.9539 mL 4.8848 mL
15 mM 0.1303 mL 0.6513 mL 1.3026 mL 3.2565 mL
20 mM 0.0977 mL 0.4885 mL 0.9770 mL 2.4424 mL
25 mM 0.0782 mL 0.3908 mL 0.7816 mL 1.9539 mL
30 mM 0.0651 mL 0.3257 mL 0.6513 mL 1.6283 mL
40 mM 0.0488 mL 0.2442 mL 0.4885 mL 1.2212 mL
50 mM 0.0391 mL 0.1954 mL 0.3908 mL 0.9770 mL
60 mM 0.0326 mL 0.1628 mL 0.3257 mL 0.8141 mL
80 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6106 mL
100 mM 0.0195 mL 0.0977 mL 0.1954 mL 0.4885 mL
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Rilmazafone hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rilmazafone85815-37-8450191SGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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상품명:
Rilmazafone hydrochloride
Cat. No.:
HY-U00228
수량:
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