1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. 5-Iminodaunorubicin hydrochloride

5-Iminodaunorubicin hydrochloride 

Cat. No.: HY-138645A
Handling Instructions

5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells.

For research use only. We do not sell to patients.

5-Iminodaunorubicin hydrochloride Chemical Structure

5-Iminodaunorubicin hydrochloride Chemical Structure

CAS No. : 67324-99-6

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Description

5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].

In Vitro

In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

563.00

Formula

C₂₇H₃₁ClN₂O₉

CAS No.
SMILES

COC(C=CC=C1C(C2=C(O)C(C[[email protected]@](C(C)=O)(C[[email protected]@H]3O[[email protected]@H]4O[[email protected]]([[email protected]]([[email protected]](C4)N)O)C)O)=C3C(O)=C52)=O)=C1C5=N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (355.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7762 mL 8.8810 mL 17.7620 mL
5 mM 0.3552 mL 1.7762 mL 3.5524 mL
10 mM 0.1776 mL 0.8881 mL 1.7762 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (8.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (8.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

5-IminodaunorubicinDNA/RNA SynthesisquinoneanthracyclineantitumorDNAInhibitorinhibitorinhibit

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Product Name:
5-Iminodaunorubicin hydrochloride
Cat. No.:
HY-138645A
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