67324-99-6
Chemical Structure
5-Iminodaunorubicin hydrochloride
- CAS No.: 67324-99-6
- Formula:C27H31ClN2O9
- Molecular Weight:563.00
IUPAC Name: (8S,10S)-8-acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-12-imino-1-methoxy-7,9,10,12-tetrahydrotetracen-5(8H)-one hydrochloride
InChIKey: KVTVLWOKIDKIQL-KOFUDPRISA-N
SMILES: COC(C=CC=C1C(C2=C(O)C(C[C@@](C(C)=O)(C[C@@H]3O[C@@H]4O[C@H]([C@H]([C@H](C4)N)O)C)O)=C3C(O)=C52)=O)=C1C5=N.[H]Cl
Biological Activity: 5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].
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5-Iminodaunorubicin hydrochloride | 95.13% | 5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells. | ||||||||||||||||||||
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- [1]. R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9. [Content Brief]
- [2]. L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91. [Content Brief]
Keywords
