AZD-5991 (S-enantiomer)
Based on 1 Customer Validation
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 2143061-82-7
- Formula: C35H34ClN5O3S2
- Molecular Weight:672.26
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Mcl-1 6.3 μM (IC50) |
Mcl-1 0.98 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
29.6 μM
Compound: 5; AZD5991
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Antiproliferative activity against human K562 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
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[PMID: 34342996] |
| MV4-11 | IC50 |
0.024 μM
Compound: 5; AZD5991
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Antiproliferative activity against human MV4-11 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
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[PMID: 34342996] |
| NCI-H23 | IC50 |
0.19 μM
Compound: 5; AZD5991
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Antiproliferative activity against human NCI-H23 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H23 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
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[PMID: 34342996] |
| NCI-H929 | IC50 |
0.036 μM
Compound: 5; AZD5991
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Antiproliferative activity against human NCI-H929 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H929 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
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[PMID: 34342996] |
| SK-BR-3 | IC50 |
30 μM
Compound: 5; AZD5991
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Antiproliferative activity against human SK-BR-3 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human SK-BR-3 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
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[PMID: 34342996] |
Chemical Information
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CAS No. 2143061-82-7
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Appearance Solid
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Molecular Weight 672.26
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Formula C35H34ClN5O3S2
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Color White to off-white
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SMILES
O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (185.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4875 mL | 7.4376 mL | 14.8752 mL | 37.1880 mL |
| 5 mM | 0.2975 mL | 1.4875 mL | 2.9750 mL | 7.4376 mL | |
| 10 mM | 0.1488 mL | 0.7438 mL | 1.4875 mL | 3.7188 mL | |
| 15 mM | 0.0992 mL | 0.4958 mL | 0.9917 mL | 2.4792 mL | |
| 20 mM | 0.0744 mL | 0.3719 mL | 0.7438 mL | 1.8594 mL | |
| 25 mM | 0.0595 mL | 0.2975 mL | 0.5950 mL | 1.4875 mL | |
| 30 mM | 0.0496 mL | 0.2479 mL | 0.4958 mL | 1.2396 mL | |
| 40 mM | 0.0372 mL | 0.1859 mL | 0.3719 mL | 0.9297 mL | |
| 50 mM | 0.0298 mL | 0.1488 mL | 0.2975 mL | 0.7438 mL | |
| 60 mM | 0.0248 mL | 0.1240 mL | 0.2479 mL | 0.6198 mL | |
| 80 mM | 0.0186 mL | 0.0930 mL | 0.1859 mL | 0.4648 mL | |
| 100 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3719 mL |
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