1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Acetazolamide-d3

Acetazolamide-d3 is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities.

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Acetazolamide-d<sub>3</sub>

Acetazolamide-d3 화학구조

CAS No. : 1189904-01-5

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
10 mg   견적 받기  
50 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Acetazolamide-d3:

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  • Biological Activity

  • 순도&문서

  • 고객리뷰

제품 설명

Acetazolamide-d3 is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

225.26

화학식

C4H3D3N4O3S2

CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(C([2H])([2H])[2H])NC1=NN=C(S(N)(=O)=O)S1

선적

Room temperature in continental US; may vary elsewhere.

보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (221.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4393 mL 22.1966 mL 44.3931 mL
5 mM 0.8879 mL 4.4393 mL 8.8786 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.9%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4393 mL 22.1966 mL 44.3931 mL 110.9829 mL
5 mM 0.8879 mL 4.4393 mL 8.8786 mL 22.1966 mL
10 mM 0.4439 mL 2.2197 mL 4.4393 mL 11.0983 mL
15 mM 0.2960 mL 1.4798 mL 2.9595 mL 7.3989 mL
20 mM 0.2220 mL 1.1098 mL 2.2197 mL 5.5491 mL
25 mM 0.1776 mL 0.8879 mL 1.7757 mL 4.4393 mL
30 mM 0.1480 mL 0.7399 mL 1.4798 mL 3.6994 mL
40 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7746 mL
50 mM 0.0888 mL 0.4439 mL 0.8879 mL 2.2197 mL
60 mM 0.0740 mL 0.3699 mL 0.7399 mL 1.8497 mL
80 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.3873 mL
100 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1098 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

상품명:
Acetazolamide-d3
Cat. No.:
HY-B0782S
수량:
MCE Japan Authorized Agent: