59-66-5
59-66-5
Chemical Structure
Acetazolamide
- CAS No.: 59-66-5
- Formula:C4H6N4O3S2
- Molecular Weight:222.25
IUPAC Name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
SMILES: CC(NC1=NN=C(S(=O)(N)=O)S1)=O
Biological Activity: Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
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Acetazolamide | 99.85% | Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
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Acetazolamide (Standard) | 99.57% | Acetazolamide (Standard) is the analytical standard of Acetazolamide. This product is intended for research and analytical applications. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
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Acetazolamide-15N,d3 | Acetazolamide-15N,d3 is the 15N and deuterium labeled isotope of Acetazolamide(15N,d3). | |||||||||||||||||||||
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Acetazolamide-d3 | 99.9% | Acetazolamide-d3 is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
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Acetazolamide-13C2,d3 | Acetazolamide-13C2,d3 is the 13C- and deuterium labeled Acetazolamide. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Diuretic effects. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-184759Methyl acetazolamide -
Similarity Score 0.89
HY-W460096Acetazolamide impurity 5 -
Similarity Score 0.78
HY-W074975RCL 5343 (Standard) -
Similarity Score 0.78
HY-W074975AAcetazolamide impurity 4 -
Similarity Score 0.76
HY-W168956Acetazolamide impurity 2 -
Similarity Score 0.75
HY-B0553Methazolamide -
Similarity Score 0.74
HY-B0553SMethazolamide-d6 -
Similarity Score 0.73
HY-W074975CL 5343 -
Similarity Score 0.71
HY-W214889Acetazolamide impurity 3 -
Explore the MedChemAI to find more analogs
References
- [1]. Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. [Content Brief]
- [4]. Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. [Content Brief]
- [5]. Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. [Content Brief]
- [6]. Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. [Content Brief]
