59-66-5
59-66-5
Chemical Structure
Acetazolamide
- CAS 番号: 59-66-5
- Formula:C4H6N4O3S2
- Molecular Weight:222.25
IUPAC Name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
SMILES: CC(NC1=NN=C(S(=O)(N)=O)S1)=O
Biological Activity: Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Acetazolamide | 99.85% | Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide (Standard) | 99.57% | Acetazolamide (Standard) is the analytical standard of Acetazolamide. This product is intended for research and analytical applications. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide-15N,d3 | Acetazolamide-15N,d3 is the 15N and deuterium labeled isotope of Acetazolamide(15N,d3). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide-d3 | 99.9% | Acetazolamide-d3 is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide-13C2,d3 | Acetazolamide-13C2,d3 is the 13C- and deuterium labeled Acetazolamide. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Diuretic effects. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methyl acetazolamide | Methyl acetazolamide (Propazolamide) is a carbonic anhydrase inhibitor with Ki values of 37.5 nM against Enterococcus faecium α-CA, 250.1 nM against Enterococcus faecium γ-CA, 235.4 nM against human CA I, and 37.2 nM against human CA II. Methyl acetazolamide can be used for the research of enterococcus infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methazolamide | 99.41% | Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methazolamide (Standard) | ≥98% | Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methazolamide-d6 | Methazolamide-d6 is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CL 5343 | 99.91% | CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide impurity 4 | Acetazolamide impurity 4 is an impurity of Acetazolamide. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CL 5343 (Standard) | ≥98% | CL 5343 (Standard) is the analytical standard of CL 5343. This product is intended for research and analytical applications. CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide impurity 2 | 98.80% | Acetazolamide impurity 2 (NSC 231656) is an impurity of Acetazolamide. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide impurity 3 | Acetazolamide impurity 3 is an impurity of Acetazolamide. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Acetazolamide impurity 5 | Acetazolamide impurity 5 is an impurity of Acetazolamide. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. [Content Brief]
- [4]. Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. [Content Brief]
- [5]. Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. [Content Brief]
- [6]. Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. [Content Brief]
