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Cat. No.: HY-184759

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Methyl acetazolamide

(Synonyms: Propazolamide)

Methyl acetazolamide (Propazolamide) is a carbonic anhydrase inhibitor with K_i values of 37.5 nM against Enterococcus faecium α-CA, 250.1 nM against Enterococcus faecium γ-CA, 235.4 nM against human CA I, and 37.2 nM against human CA II. Methyl acetazolamide can be used for the research of enterococcus infections.

For research use only. We do not sell to patients.

CAS No.: 98-75-9
Formula: C₅H₈N₄O₃S₂
Molecular Weight:236.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methyl acetazolamide Chemical Structure

CAS No.: 98-75-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

hCA I

235.4 nM (Ki)

hCA II

37.2 nM (Ki)

All Carbonic Anhydrase Isoforms :

In Vitro

Methyl acetazolamide (compound 1) inhibits recombinant Efa-CA (K_i = 37.5 nM), recombinant Efc-CA (K_i = 250.1 nM), purified hCA I (K_i = 235.4 nM), and purified hCA II (K_i = 37.2 nM), with enhanced potency relative to Acetazolamide (HY-B0782) against the bacterial carbonic anhydrase isoforms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 98-75-9
Molecular Weight 236.27
Formula C₅H₈N₄O₃S₂
SMILES

O=C(CC)NC1=NN=C(S(=O)(N)=O)S1
Synonyms

Propazolamide
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An W W, et al. Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1): 1838-1844.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Methyl acetazolamide

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Methyl acetazolamide Related Classifications

HY-184759 Related Classifications