Am or olfine-hydrochl or ide

By Targets:	IDE (5) Autophagy (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Fungal (2) Insulin Receptor (1) Interleukin Related (1) IRE1 (1) MMP (1) MOFs (1) NOD-like Receptor (NLR) (1) Organoid (3) PKC (1) Proteolytic Enzyme (1) Reference Standards (3) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (1) Tyrosinase (2)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: IDE

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101569

Darovasertib 4 Publications Verification LXS196; ide196	PKC	Cancer
Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC₅₀ values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research .

HY-169422

GSK4418959 ide275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .

HY-100533

IDE1 1 Publications Verification	Organoid	Inflammation/Immunology
IDE1 is an inducer of definitive endoderm 1.

HY-117878

ML345 1 Publications Verification	IDE NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology Endocrinology
ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC₅₀ of 188 nM against IDE. ML345 targets the Cys819 residue of *IDE* to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage .

HY-N7135

Tropolone	Tyrosinase Fungal	Metabolic Disease Inflammation/Immunology Cancer
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

HY-110197

6bK TFA 2 Publications Verification	IDE	Metabolic Disease
6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC₅₀ of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .

HY-100534

IDE 2	Organoid TGF-beta/Smad	Others
IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway .

HY-W157689

IDE-IN-2 1 Publications Verification	Proteolytic Enzyme IDE	Infection Metabolic Disease Cancer
IDE-IN-2 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-2 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .

HY-169422A

GSK4418959 (enantiomer) ide275 (enantiomer)	DNA/RNA Synthesis	Cancer
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-143401

Hit 1	IDE	Metabolic Disease
Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC₅₀ of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion .

HY-12655

IDE-IN-1	MMP	Metabolic Disease
IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC₅₀ value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes .

HY-114611

BDM44768	IRE1	Metabolic Disease
BDM44768 is an inhibitior of *IDE*. BDM44768 exacerbates ER stress-induced IRE1 activation and promotes lipid accumulation in hepatocytes. BDM44768 potentiates activation of the IRE1 pathway in the liver and exacerbates liver lipid accumulation in an acute mice model of ER stress .

HY-N7135R

Tropolone (Standard)	Tyrosinase Reference Standards Fungal	Metabolic Disease Inflammation/Immunology Cancer
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

HY-W616806

Sodium 6-oxo-3,6-dihydropurin-7-ide	Biochemical Assay Reagents	Others
Sodium 6-oxo-3,6-dihydropurin-7-ide, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

HY-RS06526

IDE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IDE Human Pre-designed siRNA Set A contains three designed siRNAs for IDE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IDE Human Pre-designed siRNA Set A IDE Human Pre-designed siRNA Set A

HY-RS16920

Ide Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ide Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ide Mouse Pre-designed siRNA Set A Ide Mouse Pre-designed siRNA Set A

HY-W103371R

*Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide* 1,1-dioxide dihydrate (Standard)** o-Sulfobenzimide sodium salt dihydrate (Standard)	Reference Standards
Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide dihydrate (Standard) is the analytical standard of Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide dihydrate. This product is intended for research and analytical applications.

HY-100533R

IDE1 (Standard)	Organoid Reference Standards	Inflammation/Immunology
IDE1 (Standard) is the analytical standard of IDE1 (HY-100533). This product is intended for research and analytical applications. IDE1 is an inducer of definitive endoderm 1.

HY-RS23363

Ide Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ide Rat Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ide Rat Pre-designed siRNA Set A Ide Rat Pre-designed siRNA Set A

HY-182280

BDM71230	Insulin Receptor	Metabolic Disease
BDM71230 is an orally active inducer of insulin-degrading enzyme (IDE), with an EC₅₀ of 1.9 μM against human IDE. BDM71230 binds to the interface of IDE dimers and enhances the catalytic activity of IDE via steric effects. BDM71230 can potentiate the hydrolytic effect of IDE on insulin and slightly attenuate the hypoglycemic effect of insulin. BDM71230 serves as a pharmacological tool for investigating IDE function and is applicable to studies related to glucose intolerance .

HY-W038421

1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene 1,3-Dimesityl-1H-imidazol-3-ium-2-ide	MOFs	Others
1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene (1,3-Dimesityl-1H-imidazol-3-ium-2-ide) is a metal-organic framework (MOF).

HY-110197A

6bK formate	IDE	Metabolic Disease
6bK formate is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC₅₀ value of 50 nM. 6bK formate increases circulating insulin in high-fat-fed mice. Acute administration of 6bK formate enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. 6bK formate can be used for type 2 diabetes research .

HY-P992056

Anti-Human/Mouse LY6E Antibody (9B12)	Autophagy	Cancer
Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRα and CD8α, specifically reduces the survival rate of peripheral CD8 ⁺ T cells and induces their activation, breaking the state of cellular quiescence; on the other hand, it recognizes and immunoprecipitates *IDE* under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8 ⁺ T cells strictly depends on the presence of PILRα, and it does not affect CD4 ⁺ T cells or T cell development in the thymus, exhibiting high specificity .

Cat. No.	Product Name	Type

HY-W616806

Sodium 6-oxo-3,6-dihydropurin-7-ide	Biochemical Assay Reagents
Sodium 6-oxo-3,6-dihydropurin-7-ide, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

Cat. No.	Product Name	Target	Research Area	Image

HY-P992056

Anti-Human/Mouse LY6E Antibody (9B12)	Autophagy	Cancer
Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRα and CD8α, specifically reduces the survival rate of peripheral CD8 ⁺ T cells and induces their activation, breaking the state of cellular quiescence; on the other hand, it recognizes and immunoprecipitates *IDE* under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8 ⁺ T cells strictly depends on the presence of PILRα, and it does not affect CD4 ⁺ T cells or T cell development in the thymus, exhibiting high specificity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7135

Tropolone	Olax imbricata Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Olacaceae Other Diseases Plants Disease Research Fields Source Classification	Tyrosinase Fungal
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

HY-N7135R

Tropolone (Standard)	Olax imbricata Structural Classification Ketones, Aldehydes, Acids Olacaceae Plants Source Classification	Tyrosinase Reference Standards Fungal
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70291

	*Insulysin/IDE* Protein, Human (HEK293, His)** rHuInsulin-degrading enzyme/ide, His ; Insulin-Degrading Enzyme; Abeta-Degrading Protease; Insulin Protease; Insulinase; Insulysin; ide	Human	HEK293
	Insulin/IDE protein is the key to the decomposition of cellular peptides. It participates in the degradation of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kinins and other peptides, and affects intercellular peptide signaling. Substrate binding induces conformational changes that promote degradation of larger substrates such as insulin. Insulysin/IDE Protein, Human (HEK293, His) is the recombinant human-derived Insulysin/IDE protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P85666

	Insulin degrading enzyme Antibody (YA5358) ide; Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin	WB, IHC-P, ICC/IF	Human, Hamster
	Insulin degrading enzyme Antibody (YA5358) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Insulin degrading enzyme.

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Cat. No.	Product Name		Classification

HY-RS06526

IDE Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IDE Human Pre-designed siRNA Set A contains three designed siRNAs for IDE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16920

Ide Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ide Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23363

Ide Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ide Rat Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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