Insulin degrading enzyme Antibody (YA5358)
(Synonyms: IDE; Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin)Insulin degrading enzyme Antibody (YA5358) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Insulin degrading enzyme.
-
Host:
Mouse
-
Application:
WB, IHC-P, ICC/IF,
-
Reactivity :
Human, Hamster
-
Formulation:
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:200 | 1:50-300 |
Product Details
Insulin degrading enzyme Antibody (YA5358) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Insulin degrading enzyme.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Hamster
-
Observed Molecular WeightObserved band size: 118 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Synthetic Peptide of IDE
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Insulin degrading enzyme plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin. Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP. Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous. Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I; (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV)[1][2][3][4][5][6][7][8][9][10][11][12][13].
-
Subcellular Localization
Cytoplasm, cytosol; Cell membrane; Secreted
-
Expression
Tissue_specificity:Protein levels were detected in both brain tissue and cerebrospinal fluid. -
Isoforms & Post-Translational Modification
P14735 has 2 isomers: P14735-1: 117968 Da (predicted); P14735-2: 54240 Da (predicted).
The N-terminus is blocked -
Subunit
Homodimer (Probable) (PubMed:17051221, PubMed:19321446, PubMed:23922390, PubMed:26394692, PubMed:29596046). Can also form homotetramers (By similarity)
-
SwissProt ID
-
Synonyms
IDE; Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin
Documentation
Powered by Bioz
