バソプレッシン (Synonyms: AVP; Argipressin; Arg8-vasopressin)

Name: Argipressin
Brand: MedChemExpress
SKU: HY-P0049
Rating: 5.0 (10 reviews)

製品番号: HY-P0049 純度: 98.71%: Data Sheet SDS COA 取扱説明書
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Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

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カスタムペプチド

CAS 番号 : 113-79-1

容量	価格（税別）	在庫状況	数量
1 mg	$66	在庫あり	Estimated Time of Arrival: December 31
5 mg	$119	在庫あり	Estimated Time of Arrival: December 31
10 mg	$158	在庫あり	Estimated Time of Arrival: December 31
25 mg	$211	在庫あり	Estimated Time of Arrival: December 31
50 mg	$251	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 10 publication(s) in Google Scholar

Other Forms of Argipressin:

Vasopressin-d₅ TFA 在庫あり
Argipressin acetate 在庫あり
Argipressin diacetate お問い合わせ

顧客検証

Cell Proliferation/Viability Assay

Cell Imaging/Staining

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; H9c2 cell viability measured 48 h after exposure to different arginine Argipressin (AVP) concentrations (0–500 µM).

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Representative images of Argipressin (AVP) (300 µM) TUNEL staining.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative Western blot images.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative fluorescence images of DCFH-DA loading and quantitative analysis of reactive oxygen species (ROS) levels in H9c2 cells of the Con and AVP groups.

: Argipressin purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2022 Dec:206:115265. [Abstract]; Argipressin (AVP) (300 µM). Representative immunofluorescence images of nuclear factor E2-associated factor 2 (Nrf2) expression in two groups of cells.

Vasopressin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

V1a Receptor V1b Receptor V2 Receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

IC₅₀ & Target

V2 Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
A7R5	IC₅₀	10 nM Compound: vasopressin, VS2	Tested for the TYR(Me)2 arginine-vasopressin as radioligand at 0.3 nM in A7r5 cells Tested for the TYR(Me)2 arginine-vasopressin as radioligand at 0.3 nM in A7r5 cells	10.1016/S0960-894X(97)00050-4
CHO	EC₅₀	2 nM Compound: AVP	Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	[PMID: 21428295]
CHO	EC₅₀	8.3 nM Compound: AVP	Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay	[PMID: 21428295]
CHO-K1	EC₅₀	15 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay Agonist activity at human OT receptor expressed in CHO-K1 cells by luciferase reporter gene assay	[PMID: 21688787]
CHO-K1	EC₅₀	22 nM Compound: AVP	Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
COS-1	EC₅₀	41 nM Compound: 2, AVP	Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay	[PMID: 21117646]
Flp-In-293	EC₅₀	4.3 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1b receptor expressed in Flp-In-293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.0035 nM Compound: AVP	Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.004 nM Compound: AVP	Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.05 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V2 receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.05 nM Compound: AVP	Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
HEK293	EC₅₀	0.07 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant rat vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.1 nM Compound: AVP	Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method	[PMID: 30896946]
HEK293	EC₅₀	0.24 nM Compound: 1, AVP, [Arg8]vasopressin	Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at recombinant human vasopressin V1a receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 21688787]
HEK293	EC₅₀	0.24 nM Compound: AVP	Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]
HEK293	EC₅₀	4.3 nM Compound: AVP	Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay	[PMID: 24874785]

体外実験

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC₅₀=5 nM)^[1]. AVP-induced [Ca²⁺]_i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca²⁺]_i responses are 100 pM in non-neuronal cells in DRG culture^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1084.23

分子式

C₄₆H₆₅N₁₅O₁₂S₂

CAS 番号

113-79-1

Appearance

Solid

Color

White to off-white

Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (92.23 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9223 mL	4.6116 mL	9.2231 mL
5 mM	0.1845 mL	0.9223 mL	1.8446 mL
10 mM	0.0922 mL	0.4612 mL	0.9223 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.71%

Select Batch:

データシート (282 KB) SDS (393 KB)

COA (259 KB) RP-HPLC (263 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. [Content Brief]

[2]. Moriya T, et al. Vasopressin-induced intracellular Ca2+ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. [Content Brief]

[3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.9223 mL	4.6116 mL	9.2231 mL	23.0578 mL
	5 mM	0.1845 mL	0.9223 mL	1.8446 mL	4.6116 mL
	10 mM	0.0922 mL	0.4612 mL	0.9223 mL	2.3058 mL
	15 mM	0.0615 mL	0.3074 mL	0.6149 mL	1.5372 mL
	20 mM	0.0461 mL	0.2306 mL	0.4612 mL	1.1529 mL
	25 mM	0.0369 mL	0.1845 mL	0.3689 mL	0.9223 mL
	30 mM	0.0307 mL	0.1537 mL	0.3074 mL	0.7686 mL
	40 mM	0.0231 mL	0.1153 mL	0.2306 mL	0.5764 mL
	50 mM	0.0184 mL	0.0922 mL	0.1845 mL	0.4612 mL
	60 mM	0.0154 mL	0.0769 mL	0.1537 mL	0.3843 mL
	80 mM	0.0115 mL	0.0576 mL	0.1153 mL	0.2882 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Argipressin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argipressin113-79-1Arg8-vasopressin AVPVasopressin ReceptorInhibitorinhibitorinhibit

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バソプレッシン (Synonyms: AVP; Argipressin; Arg8-vasopressin)

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Argipressin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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バソプレッシン (Synonyms: AVP; Argipressin; Arg8-vasopressin)

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Other Forms of Argipressin:

バソプレッシン 関連抗体

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おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Vasopressin Receptor アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

バソプレッシン 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Argipressin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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バソプレッシン関連抗体

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