Coluracetam (Synonyms: MKC-231)

Name: Coluracetam
Brand: MedChemExpress
SKU: HY-17553
Rating: 5.0 (3 reviews)

Cat. No.: HY-17553 Purity: 99.87%: Data Sheet
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Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia.

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CAS No. : 135463-81-9

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무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
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10 g	견적 받기

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고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Coluracetam:

Coluracetam (Standard) 견적 받기

3 Publications Citing Use of MCE Coluracetam

: Coluracetam purchased from MedChemExpress. Usage Cited in: J Pain Res. 2018 Sep 21:11:1971-1982. [Abstract]; Immunoblots for CHT1 in the colon of WAS and WAS-MKC-231-treated rats reveal that the ratios of CHT1 to β-actin expression in WAS rats are considerably increased after 10 consecutive days of MKC-231 treatment.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

Coluracetam (0.3-3 mg/kg, oral, once a day for 11 days) improves the memory deficits and hippocampal acetylcholine depletion in mice induced by AF64A^[1].
Coluracetam (1-3 mg/kg, oral, once a day for 8 days) improves cognitive and learning impairments in rats^[2].
Coluracetam (5×10^-8 and 5×10^-7 mol, ventricular injection, single dose) slightly increases hepatic venous glucose levels^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice induced by AF64A induced^[1]
Dosage:	0.3, 1.0, 3.0 mg/kg, once a day, for 11 days
Administration:	Oral
Result:	Improved memory deficits and significantly reversed cetylcholine depletion.

Animal Model:	Mice induced by AF64A induced^[2]
Dosage:	1.0, 3.0 mg/kg, once a day, for 8 days
Administration:	Oral
Result:	Showed the platform latency in the Morris water maze task shortened, cognitive impairment improved, and high-affinity choline uptake increased.

Animal Model:	Male albino Wistar rats^[3]
Dosage:	5×10^-8 and 5×10^-7 mol, single dose
Administration:	Intracerebroventricular injection (ICV)
Result:	Slight increased in hepatic venous glucose.

분자량

341.40

화학식

C₁₉H₂₃N₃O₃

CAS No.

135463-81-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C2C(OC(C)=C2C)=NC3=C1CCCC3)CN4C(CCC4)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : ≥ 20 mg/mL (58.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.4 mg/mL (1.17 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9291 mL	14.6456 mL	29.2912 mL
5 mM	0.5858 mL	2.9291 mL	5.8582 mL
10 mM	0.2929 mL	1.4646 mL	2.9291 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.87%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (255 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Murai S, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13. [Content Brief]

[2]. Tomoko Bessho， et al. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. [Content Brief]

[3]. K Uemura, et al. Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats. Jpn J Pharmacol. 1999 Jan;79(1):113-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.9291 mL	14.6456 mL	29.2912 mL	73.2279 mL
DMSO	5 mM	0.5858 mL	2.9291 mL	5.8582 mL	14.6456 mL
	10 mM	0.2929 mL	1.4646 mL	2.9291 mL	7.3228 mL
	15 mM	0.1953 mL	0.9764 mL	1.9527 mL	4.8819 mL
	20 mM	0.1465 mL	0.7323 mL	1.4646 mL	3.6614 mL
	25 mM	0.1172 mL	0.5858 mL	1.1716 mL	2.9291 mL
	30 mM	0.0976 mL	0.4882 mL	0.9764 mL	2.4409 mL
	40 mM	0.0732 mL	0.3661 mL	0.7323 mL	1.8307 mL
	50 mM	0.0586 mL	0.2929 mL	0.5858 mL	1.4646 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Coluracetam Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coluracetam135463-81-9MKC-231MKC231MKC 231iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Coluracetam (Synonyms: MKC-231)

고객리뷰

Other Forms of Coluracetam:

Coluracetam Related Antibodies

3 Publications Citing Use of MCE Coluracetam

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Coluracetam Related Classifications

Keywords:

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