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  4. Ethylenediaminetetraacetic acid trisodium salt

エデト酸三ナトリウム  (Synonyms: Ethylenediaminetetraacetic acid trisodium salt; EDTA trisodium salt; Trisodium EDTA)

製品番号: HY-B1009 純度: 98.0%
COA 取扱説明書 Technical Support

Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.

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CAS 番号 : 150-38-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in Water USD 44 在庫あり
Solid
500 mg $40 在庫あり
1 g $50 在庫あり
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Based on 28 publication(s) in Google Scholar

Other Forms of Ethylenediaminetetraacetic acid trisodium salt:

エデト酸三ナトリウム 関連抗体

Top Publications Citing Use of Products

顧客検証

IHC

    Ethylenediaminetetraacetic acid trisodium salt purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672.  [Abstract]

    Representative images of CHMP4–GFP puncta (arrowheads; left) and percentage of CHMP4 speckle+ (top right) or Annexin V+ (bottom right) cells in BMDMs incubated with PBS, 15 µM SK56, 2 mM EDTA or EDTA + SK56 at 2 h after the addition of 1 μg/ml LPS + 10 μM nigericin; scale bar, 50 µm; n = 5 repeats

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    製品説明

    Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

    体外実験

    Ethylenediaminetetraacetic acid has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
    Ethylenediaminetetraacetic acid (0.005-0.01 M) has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
    Ethylenediaminetetraacetic acid (1.2 mM) enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    エデト酸三ナトリウム 関連抗体
    体内実験

    Ethylenediaminetetraacetic acid (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
    Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
    Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
    Reduced fibrosis of the liver in surviving rats (20%).
    Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
    Dosage: 60 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
    Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
    Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
    Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
    Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
    分子量

    358.19

    分子式

    C10H13N2Na3O8
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)CN(CCN(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (139.59 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7918 mL 13.9591 mL 27.9181 mL
    5 mM 0.5584 mL 2.7918 mL 5.5836 mL
    10 mM 0.2792 mL 1.3959 mL 2.7918 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (139.59 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.7918 mL 13.9591 mL 27.9181 mL 69.7954 mL
    5 mM 0.5584 mL 2.7918 mL 5.5836 mL 13.9591 mL
    10 mM 0.2792 mL 1.3959 mL 2.7918 mL 6.9795 mL
    15 mM 0.1861 mL 0.9306 mL 1.8612 mL 4.6530 mL
    20 mM 0.1396 mL 0.6980 mL 1.3959 mL 3.4898 mL
    25 mM 0.1117 mL 0.5584 mL 1.1167 mL 2.7918 mL
    30 mM 0.0931 mL 0.4653 mL 0.9306 mL 2.3265 mL
    40 mM 0.0698 mL 0.3490 mL 0.6980 mL 1.7449 mL
    50 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3959 mL
    60 mM 0.0465 mL 0.2327 mL 0.4653 mL 1.1633 mL
    80 mM 0.0349 mL 0.1745 mL 0.3490 mL 0.8724 mL
    100 mM 0.0279 mL 0.1396 mL 0.2792 mL 0.6980 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ethylenediaminetetraacetic acid trisodium salt Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ethylenediaminetetraacetic acid trisodium150-38-9EDTA trisodium Trisodium EDTASODFerroptosisEnvironmental PollutantsBacterialSuperoxide DismutaseEnvironmental ContaminantsAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293TTDAG8cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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