2. GPCR/G Protein
  3. Vasopressin Receptor
  4. Felypressin

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

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Kundenspezifische Peptidsynthese

Felypressin

Felypressin Chemische Struktur

CAS. Nr. : 56-59-7

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Based on 3 publication(s) in Google Scholar

Other Forms of Felypressin:

Felypressin Related Antibodies

Top Publications Citing Use of Products

Alle Vasopressin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
V1a Receptor  V1b Receptor  V2 Receptor 

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Beschreibung

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures[1][2].

IC50 & Target

Vasopressin 1[2]
In Vitro

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Felypressin Related Antibodies
In Vivo

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

1040.22

Formel

C46H65N13O11S2
CAS. Nr.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)
Sequence Shortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 100 mg/mL (96.13 mM)

DMSO : ≥ 10.4 mg/mL (10.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9613 mL 4.8067 mL 9.6134 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.9613 mL 4.8067 mL 9.6134 mL 24.0334 mL
5 mM 0.1923 mL 0.9613 mL 1.9227 mL 4.8067 mL
H2O 15 mM 0.0641 mL 0.3204 mL 0.6409 mL 1.6022 mL
20 mM 0.0481 mL 0.2403 mL 0.4807 mL 1.2017 mL
25 mM 0.0385 mL 0.1923 mL 0.3845 mL 0.9613 mL
30 mM 0.0320 mL 0.1602 mL 0.3204 mL 0.8011 mL
40 mM 0.0240 mL 0.1202 mL 0.2403 mL 0.6008 mL
50 mM 0.0192 mL 0.0961 mL 0.1923 mL 0.4807 mL
60 mM 0.0160 mL 0.0801 mL 0.1602 mL 0.4006 mL
80 mM 0.0120 mL 0.0601 mL 0.1202 mL 0.3004 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Felypressin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Felypressin56-59-7PLV-2PLV2PLV 2Vasopressin ReceptorVasopressin 1vasoconstrictorhormonepituitaryanestheticdentalnon-catecholamineArginineInhibitorinhibitorinhibit

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