2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Heptaminol hydrochloride

Heptaminol (hydrochloride)  (Synonyms: RP-2831 hydrochloride)

製品番号: HY-B1231 純度: 98.0%
COA 取扱説明書 Technical Support

Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels.

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Heptaminol hydrochloride

Heptaminol (hydrochloride) 構造式

CAS 番号 : 543-15-7

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 在庫あり
Solution
10 mM * 1 mL in DMSO USD 38 在庫あり
Solid
25 mg $35 在庫あり
50 mg $50 在庫あり
100 mg $70 在庫あり
200 mg $106 在庫あり
500 mg $178 在庫あり
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5 g   お問い合わせ  

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Heptaminol (hydrochloride) 関連抗体

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製品説明

Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels[1][2][3].

体内実験

Heptaminol hydrochloride (12 μL; 50% water/acetone) stimulates NO synthesis from constitutive NOS and attenuates TPA-induced depletion of NK cells at the edge of the mouse ear. Heptaminol hydrochloride exerts anti-proliferative and anti-inflammatory effects on TPA, suggesting important anti-tumor function[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)[2]
Dosage: 2.5 nmol Heptaminol in 12 μL
Administration: Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment.
Result: Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
臨床実験
分子量

181.70

分子式

C8H20ClNO
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC(O)(C)CCCC(N)C.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (550.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (550.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5036 mL 27.5179 mL 55.0358 mL
5 mM 1.1007 mL 5.5036 mL 11.0072 mL
10 mM 0.5504 mL 2.7518 mL 5.5036 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (550.36 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.5036 mL 27.5179 mL 55.0358 mL 137.5894 mL
5 mM 1.1007 mL 5.5036 mL 11.0072 mL 27.5179 mL
10 mM 0.5504 mL 2.7518 mL 5.5036 mL 13.7589 mL
15 mM 0.3669 mL 1.8345 mL 3.6691 mL 9.1726 mL
20 mM 0.2752 mL 1.3759 mL 2.7518 mL 6.8795 mL
25 mM 0.2201 mL 1.1007 mL 2.2014 mL 5.5036 mL
30 mM 0.1835 mL 0.9173 mL 1.8345 mL 4.5863 mL
40 mM 0.1376 mL 0.6879 mL 1.3759 mL 3.4397 mL
50 mM 0.1101 mL 0.5504 mL 1.1007 mL 2.7518 mL
60 mM 0.0917 mL 0.4586 mL 0.9173 mL 2.2932 mL
80 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7199 mL
100 mM 0.0550 mL 0.2752 mL 0.5504 mL 1.3759 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Heptaminol hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Heptaminol543-15-7RP-2831RP2831RP 2831Adrenergic ReceptorBeta ReceptorSympathomimetic aminescatecholamine release and uptakeorthostatic hypotensionInhibitorinhibitorinhibit

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Heptaminol hydrochloride
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