543-15-7
Chemical Structure
Heptaminol hydrochloride
Synonym(s): RP-2831 hydrochloride
- CAS No.: 543-15-7
- Formula:C8H20ClNO
- Molecular Weight:181.70
IUPAC Name: 6-amino-2-methylheptan-2-ol hydrochloride
InChIKey: JZNBMCOSOXIZJB-UHFFFAOYSA-N
SMILES: CC(O)(C)CCCC(N)C.[H]Cl
Biological Activity: Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels[1][2][3].
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Heptaminol hydrochloride | 98.0% | Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels. | ||||||||||||||||||||
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Heptaminol hydrochloride (Standard) | ≥98% | Heptaminol (hydrochloride) (Standard) is the analytical standard of Heptaminol (hydrochloride). This product is intended for research and analytical applications. Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels. | ||||||||||||||||||||
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References
- [1]. Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49(3):127-138. [Content Brief]
- [2]. Chung JF, et al. NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil. Oncotarget. 2016 Jul 26;7(30):47576-47585. [Content Brief]
- [3]. Reiter M. Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel [Indirect sympathomimetic effect of heptaminol on heart muscle]. Naunyn Schmiedebergs Arch Pharmakol. 1970;267(2):114-22. German. [Content Brief]
