Heptaminol hydrochloride
Based on 1 Customer Validation
Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 543-15-7
- Formula: C8H20ClNO
- Molecular Weight:181.70
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)[2]
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Dosage:2.5 nmol Heptaminol in 12 μL
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Administration:Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment.
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Result:Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 543-15-7
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Appearance Solid
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Molecular Weight 181.70
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Formula C8H20ClNO
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Color White to off-white
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SMILES
CC(O)(C)CCCC(N)C.[H]Cl
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Synonyms
RP-2831 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (550.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (550.36 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (550.36 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Pourrias B, et al. Heptaminol chlorhydrate: new data. Ann Pharm Fr. 1991;49(3):127-138. [Content Brief]
[2]. Chung JF, et al. NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil. Oncotarget. 2016 Jul 26;7(30):47576-47585. [Content Brief]
[3]. Reiter M. Die indirekt sympathicomimetische Wirkung von Heptaminol auf den Herzmuskel [Indirect sympathomimetic effect of heptaminol on heart muscle]. Naunyn Schmiedebergs Arch Pharmakol. 1970;267(2):114-22. German. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.5036 mL | 27.5179 mL | 55.0358 mL | 137.5894 mL |
| 5 mM | 1.1007 mL | 5.5036 mL | 11.0072 mL | 27.5179 mL | |
| 10 mM | 0.5504 mL | 2.7518 mL | 5.5036 mL | 13.7589 mL | |
| 15 mM | 0.3669 mL | 1.8345 mL | 3.6691 mL | 9.1726 mL | |
| 20 mM | 0.2752 mL | 1.3759 mL | 2.7518 mL | 6.8795 mL | |
| 25 mM | 0.2201 mL | 1.1007 mL | 2.2014 mL | 5.5036 mL | |
| 30 mM | 0.1835 mL | 0.9173 mL | 1.8345 mL | 4.5863 mL | |
| 40 mM | 0.1376 mL | 0.6879 mL | 1.3759 mL | 3.4397 mL | |
| 50 mM | 0.1101 mL | 0.5504 mL | 1.1007 mL | 2.7518 mL | |
| 60 mM | 0.0917 mL | 0.4586 mL | 0.9173 mL | 2.2932 mL | |
| 80 mM | 0.0688 mL | 0.3440 mL | 0.6879 mL | 1.7199 mL | |
| 100 mM | 0.0550 mL | 0.2752 mL | 0.5504 mL | 1.3759 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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