2. Others Vitamin D Related/Nuclear Receptor Anti-infection
  3. Fungal Pregnane X Receptor (PXR) Environmental Pollutants
  4. Imazalil

イマザリル  (Synonyms: Imazalil; エニルコナゾール; Enilconazole)

製品番号: HY-B1134 純度: 99.54%
COA 取扱説明書 Technical Support

Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.

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Imazalil

イマザリル 構造式

CAS 番号 : 35554-44-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in DMSO USD 44 在庫あり
Solid
100 mg $40 在庫あり
500 mg $80 在庫あり
1 g $120 在庫あり
5 g $240 在庫あり
10 g $350 在庫あり
25 g $700 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of Imazalil:

イマザリル 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].

体外実験

Imazalil (Enilconazole; 3, 10, 30 μM; for 6 h) significantly suppressed IL-17 mRNAs[1].
imazalil (1, 3, 10, 30, 100 μM; for 24 h) dose-dependently induces the reporter gene expression only in mPXR-expressed HepG2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

イマザリル 関連抗体

RT-PCR[1]

Cell Line: EL4 cells
Concentration: 3, 10, 30 μM
Incubation Time: 6 h
Result: Significantly suppressed IL-17 mRNAs.
体内実験

Imazalil (Enilconazole; 25-100 mg/kg; ip) significantly increases hepatic Cyp3a11 mRNA levels in a dose-dependent manner[2].
Imazalil (75 mg/kg; ip; twice; once a day) combined with TCPOBOP (3 mg/kg) much greatly increased the number of Ki-67-positive nuclei and Mcm2 mRNA levels compared to its single treatment. Imazalil accelerates hepatocyte proliferation mediated by TCPOBOP treatment in mice[2].
Imazalil (0.1, 0.5, or 2.5 mg/kg in drinking water for 15 weeks) induces oxidative stress and caused the disorders of bile acid metabolism in male adult C57BL/6 mice [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IMZ Male C57BL/6N mice[2]
Dosage: 25, 50, 75, 100 mg/kg
Administration: Intraperitoneally; single dose
Result: Significantly increased hepatic Cyp3a11 mRNA levels in a dose-dependent manner.
分子量

297.18

分子式

C14H14Cl2N2O
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (336.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (67.30 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3650 mL 16.8248 mL 33.6496 mL
5 mM 0.6730 mL 3.3650 mL 6.7299 mL
10 mM 0.3365 mL 1.6825 mL 3.3650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 1 mg/mL (3.36 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3650 mL 16.8248 mL 33.6496 mL 84.1241 mL
5 mM 0.6730 mL 3.3650 mL 6.7299 mL 16.8248 mL
10 mM 0.3365 mL 1.6825 mL 3.3650 mL 8.4124 mL
15 mM 0.2243 mL 1.1217 mL 2.2433 mL 5.6083 mL
20 mM 0.1682 mL 0.8412 mL 1.6825 mL 4.2062 mL
25 mM 0.1346 mL 0.6730 mL 1.3460 mL 3.3650 mL
30 mM 0.1122 mL 0.5608 mL 1.1217 mL 2.8041 mL
40 mM 0.0841 mL 0.4206 mL 0.8412 mL 2.1031 mL
50 mM 0.0673 mL 0.3365 mL 0.6730 mL 1.6825 mL
60 mM 0.0561 mL 0.2804 mL 0.5608 mL 1.4021 mL
DMSO 80 mM 0.0421 mL 0.2103 mL 0.4206 mL 1.0516 mL
100 mM 0.0336 mL 0.1682 mL 0.3365 mL 0.8412 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imazalil Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imazalil35554-44-0EnilconazoleFungalPregnane X Receptor (PXR)Environmental PollutantsPregnane X ReceptorEnvironmental ContaminantsFungicidemPXRmCARabnormalitiesgut microbiota dysbiosishepatic metabolism disorderInhibitorinhibitorinhibit

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