35554-44-0
35554-44-0
Chemical Structure
Imazalil
Synonym(s): Enilconazole
- CAS No.: 35554-44-0
- Formula:C14H14Cl2N2O
- Molecular Weight:297.18
IUPAC Name: 1-(2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
InChIKey: PZBPKYOVPCNPJY-UHFFFAOYSA-N
SMILES: C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2
Biological Activity: Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Imazalil | 99.54% | Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder. | ||||||||||||||||||||
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Imazalil (Standard) | ≥98% | Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder. | ||||||||||||||||||||
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AFK-108 | AFK-108 is a potent antifungal agent. AFK-108 inhibits the activity of 14 alpha-demethylase. | |||||||||||||||||||||
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Tioconazole | 99.86% | Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy. | ||||||||||||||||||||
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Econazole nitrate (Standard) | ≥98% | Econazole (nitrate) (Standard) is the analytical standard of Econazole (nitrate). This product is intended for research and analytical applications. Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity. | ||||||||||||||||||||
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Miconazole (Standard) | 99.80% | Miconazole (Standard) is the analytical standard of Miconazole. This product is intended for research and analytical applications. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects. | ||||||||||||||||||||
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Econazole | 99.93% | Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage. | ||||||||||||||||||||
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Imazalil sulfate | 99.63% | Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder. | ||||||||||||||||||||
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Imazalil-d5 sulfate | Imazalil-d5 (sulfate) is the deuterium labeled Imazalil sulfate. | |||||||||||||||||||||
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Adrenergic a2C receptor agonist-1 | 99.88% | Adrenergic a2C receptor agonist-1 (compound 13) is an agonist targeting the adrenergic receptor a2C. | ||||||||||||||||||||
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Isoconazole | Isoconazole is an antifungal agent against Candida albicans. Isoconazole is a broad-spectrum antimicrobial azole that can be studied in research on dermatomycoses. | |||||||||||||||||||||
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References
- [1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45. [Content Brief]
- [2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450. [Content Brief]
- [3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658. [Content Brief]
