Imazalil sulfate  (Synonyms: Enilconazolel sulfate)

Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder^[1][2][3].

Imazalil (Enilconazole; 3, 10, 30 μM; for 6 h) sulfate significantly suppressed IL-17 mRNAs^[1].
imazalil (1, 3, 10, 30, 100 μM; for 24 h) sulfate dose-dependently induces the reporter gene expression only in mPXR-expressed HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imazalil (Enilconazole; 25-100 mg/kg; IP) sulfate significantly increases hepatic Cyp3a11 mRNA levels in a dose-dependent manner^[2].
Imazalil (75 mg/kg; ip; twice; once a day) sulfate combined with TCPOBOP (3 mg/kg) much greatly increased the number of Ki-67-positive nuclei and Mcm2 mRNA levels compared to its single treatment. Imazalil sulfate accelerates hepatocyte proliferation mediated by TCPOBOP treatment in mice^[2].
Imazalil (0.1, 0.5, or 2.5 mg/kg in drinking water for 15 weeks) sulfate induces oxidative stress and caused the disorders of bile acid metabolism in male adult C57BL/6 mice ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

395.26

C₁₄H₁₆Cl₂N₂O₅S

58594-72-2

C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2.O=S(O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45.  [Content Brief]

  [2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450.  [Content Brief]

  [3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658.  [Content Brief]