Imazalil sulfate
Based on 1 publication(s) in Google Scholar
Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
For research use only. We do not sell to patients.
- Purity: 99.63%
- CAS No.: 58594-72-2
- Formula: C14H16Cl2N2O5S
- Molecular Weight:395.26
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Imazalil sulfate
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Biological Activity
Imazalil (Enilconazole; 3, 10, 30 μM; for 6 h) sulfate significantly suppressed IL-17 mRNAs[1].
imazalil (1, 3, 10, 30, 100 μM; for 24 h) sulfate dose-dependently induces the reporter gene expression only in mPXR-expressed HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:EL4 cells
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Concentration:3, 10, 30 μM
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Incubation Time:6 h
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Result:Significantly suppressed IL-17 mRNAs.
Imazalil (75 mg/kg; ip; twice; once a day) sulfate combined with TCPOBOP (3 mg/kg) much greatly increased the number of Ki-67-positive nuclei and Mcm2 mRNA levels compared to its single treatment. Imazalil sulfate accelerates hepatocyte proliferation mediated by TCPOBOP treatment in mice[2].
Imazalil (0.1, 0.5, or 2.5 mg/kg in drinking water for 15 weeks) sulfate induces oxidative stress and caused the disorders of bile acid metabolism in male adult C57BL/6 mice [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IMZ Male C57BL/6N mice[2]
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Dosage:25, 50, 75, 100 mg/kg
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Administration:Intraperitoneally; single dose
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Result:Significantly increased hepatic Cyp3a11 mRNA levels in a dose-dependent manner.
Chemical Information
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CAS No. 58594-72-2
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Appearance Solid
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Molecular Weight 395.26
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Formula C14H16Cl2N2O5S
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Color White to off-white
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SMILES
C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2.O=S(O)(O)=O
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Synonyms
Enilconazolel sulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Matrix-Assisted Laser Desorption Ionization Imaging and Laser Ablation Sampling for Analysis of Fungicide Distribution in Apples. [Abstract]2019 May 7;91(9):6051-6056. PMID: 30969757
Solvent & Solubility
DMSO : 116.67 mg/mL (295.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (863 KB)
- English - EN (863 KB)
- Français - FR (863 KB)
- Deutsch - DE (863 KB)
- Norwegian - NO (863 KB)
- Español - ES (863 KB)
- Swedish - SV (863 KB)
- Italian - IT (863 KB)
- Korean - KR (863 KB)
- Portuguese - PT (863 KB)
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Handling Instructions (2659 KB)
References
[1]. Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45. [Content Brief]
[2]. Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43(7):443-450. [Content Brief]
[3]. Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33(6):650-658. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5300 mL | 12.6499 mL | 25.2998 mL | 63.2495 mL |
| 5 mM | 0.5060 mL | 2.5300 mL | 5.0600 mL | 12.6499 mL | |
| 10 mM | 0.2530 mL | 1.2650 mL | 2.5300 mL | 6.3250 mL | |
| 15 mM | 0.1687 mL | 0.8433 mL | 1.6867 mL | 4.2166 mL | |
| 20 mM | 0.1265 mL | 0.6325 mL | 1.2650 mL | 3.1625 mL | |
| 25 mM | 0.1012 mL | 0.5060 mL | 1.0120 mL | 2.5300 mL | |
| 30 mM | 0.0843 mL | 0.4217 mL | 0.8433 mL | 2.1083 mL | |
| 40 mM | 0.0632 mL | 0.3162 mL | 0.6325 mL | 1.5812 mL | |
| 50 mM | 0.0506 mL | 0.2530 mL | 0.5060 mL | 1.2650 mL | |
| 60 mM | 0.0422 mL | 0.2108 mL | 0.4217 mL | 1.0542 mL | |
| 80 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.7906 mL | |
| 100 mM | 0.0253 mL | 0.1265 mL | 0.2530 mL | 0.6325 mL |
Imazalil sulfate Related Classifications
HY-B1134A Related Classifications
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