1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

MMAD (Synonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)

Cat. No.: HY-15581 Purity: 99.28%
Data Sheet SDS Handling Instructions

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

For research use only. We do not sell to patients.
MMAD Chemical Structure

MMAD Chemical Structure

CAS No. : 203849-91-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $509 In-stock
5 mg $350 In-stock
10 mg $600 In-stock
50 mg $1700 In-stock
100 mg $2800 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of MMAD:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

IC50 & Target

Tubulin[1]

In Vitro

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

In Vivo

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.2969 mL 6.4846 mL 12.9692 mL
5 mM 0.2594 mL 1.2969 mL 2.5938 mL
10 mM 0.1297 mL 0.6485 mL 1.2969 mL
References
M.Wt

771.06

Formula

C₄₁H₆₆N₆O₆S

CAS No.

203849-91-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 24.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MMAD
Cat. No.:
HY-15581
Quantity: