1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

MMAD (Synonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)

Cat. No.: HY-15581 Purity: 99.92%
Handling Instructions

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

For research use only. We do not sell to patients.

MMAD Chemical Structure

MMAD Chemical Structure

CAS No. : 203849-91-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 424 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of MMAD:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

IC50 & Target


In Vitro

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

In Vivo

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

Solvent & Solubility
In Vitro: 

DMSO : 24.5 mg/mL (31.77 mM; Need ultrasonic and warming)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2969 mL 6.4846 mL 12.9692 mL
5 mM 0.2594 mL 1.2969 mL 2.5938 mL
10 mM 0.1297 mL 0.6485 mL 1.2969 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C([[email protected]](C)[[email protected]]([[email protected]]1([H])CCCN1C(C[[email protected]@H](OC)[[email protected]]([[email protected]@H](C)CC)N(C([[email protected]@H](NC([[email protected]@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[[email protected]@H](CC2=CC=CC=C2)C3=NC=CS3


4°C, stored under nitrogen


Room temperature in continental US; may vary elsewhere

Purity: 99.92%

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Cat. No.: HY-15581