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Products are for research use only. Not for human use. We do not sell to patients.
(Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)
MMAD Chemical Structure
|Product name: MMAD|
|Cat. No.: HY-15581|
Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
Target: Tubulin; ADCs toxin
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
|M.Wt||771.06||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≤ 24.5 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||1.2969 mL||6.4846 mL||12.9692 mL|
|5 mM||0.2594 mL||1.2969 mL||2.5938 mL|
|10 mM||0.1297 mL||0.6485 mL||1.2969 mL|
CAS No.: 173441-26-4 In-stock
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