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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

MMAD

HY-15581

(Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)

MMAD

MMAD Chemical Structure

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $509 In-stock
5 mg $350 In-stock
10 mg $600 In-stock
50 mg $1700 In-stock
100 mg $2800 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €499 In-stock
5 mg €343 In-stock
10 mg €588 In-stock
50 mg €1666 In-stock
100 mg €2744 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: MMAD
Cat. No.: HY-15581

MMAD Data Sheet

  • View current batch:

    Purity: 99.92%

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    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of MMAD

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
IC50 value:
Target: Tubulin; ADCs toxin
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
 

Chemical Information

M.Wt 771.06 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₁H₆₆N₆O₆S
CAS No 203849-91-6
Solvent & Solubility

DMSO: ≤ 24.5 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.2969 mL 6.4846 mL 12.9692 mL
5 mM 0.2594 mL 1.2969 mL 2.5938 mL
10 mM 0.1297 mL 0.6485 mL 1.2969 mL

References on MMAD

Other Forms

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