2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Naloxone hydrochloride

ナロキソン塩酸塩  (Synonyms: Naloxone (hydrochloride))

製品番号: HY-17417 純度: 99.96%
COA 取扱説明書 Technical Support

Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias.

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CAS 番号 : 357-08-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
100 mg $50 在庫あり
500 mg $150 在庫あり
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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of Naloxone hydrochloride:

ナロキソン塩酸塩 関連抗体

Top Publications Citing Use of Products

    Naloxone hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074.  [Abstract]

    Heatmaps shows the calcium signals within the 10-25 min after drugs injection (i.t., 0.3 nmol Morphine, 10 nmol Naloxone + 0.3 nmol Morphine, and 10 μg NPY + 0.3 nmol Morphine), n = 5 mice per group.

    Naloxone hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 17;30(11):3625-3631.e6.   [Abstract]

    NSCs were treated with different concentrations of Naloxone, Morphine, Naloxone and Morphine (Mor+Nal, 1:1), or Nal-M. Cell numbers were determined on day 3.

    Naloxone hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2020 Mar 17;30(11):3625-3631.e6.   [Abstract]

    Neural stem cells (NSCs) were treated with 1 μM Naloxone or Morphine. The contents of 5mC and 5hmC in NSCs (day 3) were determined by high-spot Western blot assay.

    Naloxone hydrochloride purchased from MedChemExpress. Usage Cited in: Eur J Pain. 2017 May;21(5):804-814.  [Abstract]

    The SCS1 (early SCS)-mediated increase in the ipsilateral:contralateral PWT ratio (compared to pre-SCS) is significantly reduced by the opioid receptor antagonist, Naloxone, which is administered 10 min before SCS1.

    Opioid Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

    • 生物活性

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias[1].

    体内実験

    Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP)[1]. Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat[2]. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    363.84

    分子式

    C19H22ClNO4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=C(O2)C([C@]([C@]2([H])C(CC3)=O)(CCN4CC=C)[C@]3(O)[C@H]4C5)=C5C=C1.Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 62.5 mg/mL (171.78 mM; Need ultrasonic)

    DMSO : ≥ 30 mg/mL (82.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7485 mL 13.7423 mL 27.4846 mL
    5 mM 0.5497 mL 2.7485 mL 5.4969 mL
    10 mM 0.2748 mL 1.3742 mL 2.7485 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

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    濃度 （終了）

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    体積 （終了）

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    体内:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      Naloxone is made up in a vehicle of 2% dimethylformamide (aqueous)[4].

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.96%

    COA (261 KB) HNMR (262 KB) RP-HPLC (283 KB) MS (69 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [2]

    Young adult Wistar rats are used in the assay: females for experiments l and 3 (age 50-70 days, weight 100-185 g) and males for experiments 2 and 4 (age 51-69 days, weight 140-200 g). The same apparatus is used for both: a 50×25×25 cm box made of plywood with a frontal glass wall, whose floor consists of 1 mm-caliber bronze bars spaced l0 mm apart. In task l, a 5 cm high, 25×25 cm wooden platform is introduced into the box so as to cover the left half of the grid. Rats are held gently by their bodies and loared onto the platform facing the rear left corner, at which time a quartz chronometer is activated. Time is counted until the animals stepped down from the platform and placed their four paws on the grid, upon which a 0.5 mA, 60 Hz footshock is continuously delivered until the animals return to the platform. In task 2 the platform is only 7 cm wide and covered only the leftmost seven bars of the grid; the footshock is of only 0.3 mA and is delivered in 0.4 msec pulses once every 2 sec until the animals climb back onto the platform. Immediately after training in each task the animals are withdrawn from the box injected i.p. with one of the following: saline (1.0 mL/kg), ACTH1-24 (0.2 or 2.0 μg/kg), epinephrine HCl (5.0 or 50.0 μg/kg), human β-endorphin (0.1 or 1.0 μg/kg), naloxone HCl (0.4 mg/kg), or ACTH or epinephrine given together with either β-endorphin or naloxone. All drugs are dissolved in saline to an injection volume of 1.0 mL/kg. Twenty-four hr after training the animals again are placed on the platform (the wide one for task 1, experiments 1 and 2, and the narrow one for task 2, experiments 3 and 4), and their latency to stepdown onto the grid again is measured as in the training session. A ceiling of 180 sec is imposed on this measure.

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.7485 mL 13.7423 mL 27.4846 mL 68.7115 mL
    5 mM 0.5497 mL 2.7485 mL 5.4969 mL 13.7423 mL
    10 mM 0.2748 mL 1.3742 mL 2.7485 mL 6.8712 mL
    15 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5808 mL
    20 mM 0.1374 mL 0.6871 mL 1.3742 mL 3.4356 mL
    25 mM 0.1099 mL 0.5497 mL 1.0994 mL 2.7485 mL
    30 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL
    40 mM 0.0687 mL 0.3436 mL 0.6871 mL 1.7178 mL
    50 mM 0.0550 mL 0.2748 mL 0.5497 mL 1.3742 mL
    60 mM 0.0458 mL 0.2290 mL 0.4581 mL 1.1452 mL
    80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8589 mL
    H2O 100 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6871 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Naloxone hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Naloxone357-08-4Opioid ReceptorInhibitorinhibitorinhibit

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