2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Oxytocin Receptor Endogenous Metabolite
  4. Oxytocin acetate

Oxytocin (acetate)  (Synonyms: 酢酸オキシトシン; α-Hypophamine (acetate); Oxytocic hormone (acetate))

製品番号: HY-17571A 純度: 99.62%
COA 取扱説明書 Technical Support

Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

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カスタムペプチド

CAS 番号 : 6233-83-6

容量 価格（税別） 在庫状況 数量
5 mg $50 在庫あり
10 mg $70 在庫あり
25 mg $112 在庫あり
50 mg $158 在庫あり
100 mg $230 在庫あり
200 mg $350 在庫あり
500 mg $700 在庫あり
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カスタマーレビュー

Based on 24 publication(s) in Google Scholar

Other Forms of Oxytocin acetate:

Oxytocin (acetate) 関連抗体

Top Publications Citing Use of Products

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2024 May 25;14(1):208.  [Abstract]

    Trajectories of PEL-treated group (n = 6), AVP-supplemented group (n = 6), Oxytocin acetate (administered intraperitoneally 1 mg/kg/d for i.p., 50 ng for hippocampal stereotactic injection)-supplemented group (n = 6), and ATO group (n = 6) in the MWM place navigation experiment.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2024 May 25;14(1):208.  [Abstract]

    Trajectories of PEL-treated group (n = 6), AVP-supplemented group (n = 6), Oxytocin acetate (administered intraperitoneally 1 mg/kg/d for i.p., 50 ng for hippocampal stereotactic injection)-supplemented group (n = 6), and ATO group (n = 6) in the MWM spatial exploration experiment. The shaded part is the area around the platform, and the activity time of mice in the shaded part is calculated.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2024 May 25;14(1):208.  [Abstract]

    Validation of activation of endogenous Oxytocin acetate neurons in mice with PVN Oxytocin acetate neurons activated after PEL surgery.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138.  [Abstract]

    Expression of OT (Oxytocin) signaling related genes in the hippocampus. RT-PCR analysis were performed on brain tissues from the hippocampus. Con: control; Veh: Vehicle (Saline); RIS: Risperidone; LOT: Low dose (6 μg/kg) of OT; MOT: Medium dose (20 μg/kg) of OT; HOT: High dose (60 μg/kg) of OTAfter 1 week of acclimation, animals in the control group were administered saline (10 ml/kg) and those in the model group were administered MK801 (0.6 mg/kg) through intraperitoneal (i. p.) injections once a day for 21 days. One week after MK801 administration, 6 μg/kg OT (LOT group, n = 10), 20 μg/kg OT (MOT group, n = 10), or 60 μg/kg OT (HOT group, n = 10) was given through the i.n. route twice daily, at 8:30–9:30 AM and 4:00–5:00 PM, for 14 days. Saline (0.2 μL/g) was administered intranasally in the control and vehicle groups. Then, the mice received an i.p. injection of MK801 30 min after OT administration. The mice in the RIS group received an i.p. injection of 0.3 mg/kg RIS once daily for 14 days

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138.  [Abstract]

    Effects of chronic intranasal OT (Oxytocin) on levels of spontaneous activity and anxiety-like behaviors in MK801-induced mice Fig. A, the total distance traveled by the mice in the open field test. Fig. 2B, the ratio of distance traveled in the central versus peripheral zone by the mice in the open field test. Con: control; Veh: Vehicle (Saline); RIS: Risperidone; LOT: Low dose (6 μg/kg) of OT; MOT: Medium dose (20 μg/kg) of OT; HOT: High dose (60 μg/kg) of OTAfter 1 week of acclimation, animals in the control group were administered saline (10 ml/kg) and those in the model group were administered MK801 (0.6 mg/kg) through intraperitoneal (i.p.) injections once a day for 21 days. One week after MK801 administration, 6 μg/kg OT (LOT group, n = 10), 20 μg/kg OT (MOT group, n =10), or 60 μg/kg OT (HOT group, n = 10) was giventhrough the i.n. route twice daily, at 8:30–9:30 AM and 4:00–5:00 PM, for 14 days. Saline (0.2 μL/g) was administered intranasally in the control and vehicle groups. Then, the mice received ani.p. injection of MK801 30 min after OT administration. The mice in the RIS group received an i.p. injection of 0.3 mg/kg RIS once daily for 14 days.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Jan 2;8(1):3.  [Abstract]

    Representative heatmaps showing the duration and location of the shControl and shScgn mice during the 10 min social novelty recognition test. Warmer colors (red) indicate a greater amount of time spent exploring by the mice. shControl: PVN Control-shRNA injection mouse. shScgn: PVN Scgn-shRNA injection mouse. DMSO: 0.1% DMSO administration. Oxytocin acetate: 1 mg/kg Oxytocin administration. S1: a familiar mouse. S2: a novel mouse.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Jan 2;8(1):3.  [Abstract]

    Statistics of marbles burying numbers in shControl and shScgn mice treated with DMSO or Oxytocin acetate.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84.  [Abstract]

    Effect of OT on CGRP and c-fos expression levels. A and C show c-fos, B and D show CGRP. Immunofluorescence staining showed that the number of c-fos-positive cells per FOV and the average fluorescence intensity of CGRP were significantly increased in the NTG + vehicle group compared with the sham group. OT administration significantly reduced the expression of CGRP and c-fos, while these effects were prevented after adding L368,899. Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84.  [Abstract]

    WB data quantification in the mouse trigeminal nucleus caudalis. Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

    Oxytocin acetate purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2021 Jul 27;22(1):84.  [Abstract]

    OT ameliorated pain sensitization and reduced neuronal activation via OTR. Note that L-368,899 was intraperitoneally injected daily 1 h before OT treatment. The mechanical and thermal pain thresholds of the hind paw and periorbital area were assessed before each NTG injection and on day 11. B, C, D The basal mechanical pain thresholds of the hind paw (B), periorbital area (C), and the thermal pain response of the hind paw (D) were significantly increased in the NTG + OT group compared with the NTG + vehicle group.The pain threshold in the NTG + OT + L368,899 group was markedly decreased compared with the NTG + OT group.Repeated OT (Oxytocin, 20 µg/kg) treatments were quickly administered at 2 µL per nostril or the same volume of saline every two minutes using the tip of the pipette 30 min before NTG and then once daily at the same time point for 11 days.C57BL/6 mice weighing 20 ~ 30 g and 6 ~ 8 weeks of age.

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    製品説明

    Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    体内実験

    During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only[1].
    Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Fifty-six male Lister-hooded rats (150–200 g)[1]
    Dosage: 0.1 mg/kg-0.3 mg/kg
    Administration: Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
    Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
    臨床実験
    分子量

    1067.24

    分子式

    C45H70N12O14S2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)
    Sequence Shortening

    CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Sealed storage, away from moisture
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 125 mg/mL (117.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9370 mL 4.6850 mL 9.3700 mL
    5 mM 0.1874 mL 0.9370 mL 1.8740 mL
    10 mM 0.0937 mL 0.4685 mL 0.9370 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    一般には略語で表示されます：C1V1 = C2V2

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (1.95 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.9370 mL 4.6850 mL 9.3700 mL 23.4249 mL
    5 mM 0.1874 mL 0.9370 mL 1.8740 mL 4.6850 mL
    10 mM 0.0937 mL 0.4685 mL 0.9370 mL 2.3425 mL
    15 mM 0.0625 mL 0.3123 mL 0.6247 mL 1.5617 mL
    20 mM 0.0468 mL 0.2342 mL 0.4685 mL 1.1712 mL
    25 mM 0.0375 mL 0.1874 mL 0.3748 mL 0.9370 mL
    30 mM 0.0312 mL 0.1562 mL 0.3123 mL 0.7808 mL
    40 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.5856 mL
    50 mM 0.0187 mL 0.0937 mL 0.1874 mL 0.4685 mL
    60 mM 0.0156 mL 0.0781 mL 0.1562 mL 0.3904 mL
    80 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2928 mL
    100 mM 0.0094 mL 0.0468 mL 0.0937 mL 0.2342 mL
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    Oxytocin acetate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oxytocin6233-83-6α-HypophamineOxytocic hormoneOxytocin ReceptorEndogenous MetaboliteOXTRhypothalamic peptideparturitionlactationprosocial behavioranti-inflammatoryantioxidantprotectivetraumaInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-17571A
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