2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101355A
    CGP 20712 dihydrochloride 1216905-73-5 99.4%
    CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors.
    CGP 20712 dihydrochloride
  • HY-111271A
    L 888607 Racemate 1030017-51-6 99.81%
    L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
    L 888607 Racemate
  • HY-114161A
    H-Val-Pro-Pro-OH TFA 2828433-08-3 ≥98.0%
    H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
    H-Val-Pro-Pro-OH TFA
  • HY-17043S1
    Loratadine-d5 1398065-63-8 99.96%
    Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
    Loratadine-d5
  • HY-N0583S1
    Hydrocortisone-d7
    Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone-d7
  • HY-W002039
    3-Amino-3-phenylpropionic acid 614-19-7
    3-Amino-3-phenylpropionic acid (DL-β-Phenylalanine) is a structural GABA analogue. 3-Amino-3-phenylpropionic acid inhibits baclofen (HY-B0007) induced gastric acid secretion.
    3-Amino-3-phenylpropionic acid
  • HY-150012S1
    N-Lactoyl-phenylalanine-13C6 98.47%
    N-Lactoyl-phenylalanine-13C6 (Lac-Phe-13C6) is 13C labeled N-Lactoyl-phenylalanine. N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance.
    N-Lactoyl-phenylalanine-13C6
  • HY-W006492S
    5a-Pregnane-3,20-dione-d6 203850-92-4 99.0%
    5a-Pregnane-3,20-dione-d6 is the deuterium labeled 5a-Pregnane-3,20-dione. 5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.
    5a-Pregnane-3,20-dione-d6
  • HY-W010841R
    Levocetirizine dihydrochloride (Standard) 130018-87-0 99.71%
    Levocetirizine (dihydrochloride) (Standard) is the analytical standard of Levocetirizine (dihydrochloride). This product is intended for research and analytical applications. Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.
    Levocetirizine dihydrochloride (Standard)
  • HY-W088011B
    Sodium glycolate, 98% 2836-32-0 98.0%
    Sodium glycolate, 98% (Sodium hydroxyacetate, 98%) is an orally active, versatile organic salt. Sodium glycolate, 98% acts as an enzyme activity regulator that increases the activities of glycolate oxidase (GAO) and lactate dehydrogenase (LDH), while reducing the activity of glycolate dehydrogenase (GAD). Sodium glycolate, 98% induces oxalate biosynthesis and causes hyperoxaluria in rats. Sodium glycolate, 98% reduces urinary calcium excretion in male albino rats. Sodium glycolate, 98% can be used in studies related to calcium oxalate urolithiasis and hyperoxaluria.
    Sodium glycolate, 98%
  • HY-15462
    SRT3109 1204707-71-0 99.68%
    SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.
    SRT3109
  • HY-15853
    MK-7246 1218918-62-7 99.63%
    MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
    MK-7246
  • HY-B1022
    Dimesna 16208-51-8 98.0%
    Dimesna (BNP-7787), the disulfide form of Mesna (HY-13679), is a platinum-related toxicity protective agent. Dimesna converts to Mesna, which in turn inactivates toxic platinum substances. Dimesna does not interfere with the antitumor activity of platinum compounds. Dimesna does not affect the antiproliferative effects of Cisplatin (HY-17394) or Carboplatin (HY-17393). Dimesna counteracts Cisplatin-induced nephrotoxicity. Dimesna exerts selective protective effects on the kidneys. Dimesna can be used in studies related to ovarian cancer and Cisplatin-induced nephrotoxicity.
    Dimesna
  • HY-B1895
    Levodropropizine 99291-25-5 99.89%
    Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
    Levodropropizine
  • HY-N6709
    Zeranol 26538-44-3 98.82%
    Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity.
    Zeranol
  • HY-N8593
    Undecane 1120-21-4 99.66%
    Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.
    Undecane
  • HY-Y1324
    Sodium phosphate dibasic dodecahydrate 10039-32-4 98.0%
    Phosphoric acid disodium dodecahydrate is an inorganic compound and food additive. Phosphoric acid disodium dodecahydrate promotes gel formation, improves food texture and thermal properties of materials. Phosphoric acid disodium dodecahydrate induces glomerular calcification. Phosphoric acid disodium dodecahydrate can be used in kidney disease research.
    Sodium phosphate dibasic dodecahydrate
  • HY-Z0833
    Bazedoxifene N-Oxide 1174289-22-5
    Bazedoxifene N-Oxide is the oxidative degradation product of selective estrogen receptor modulator (SERM) Bazedoxifene.
    Bazedoxifene N-Oxide
  • HY-108952
    17,17-(Ethylenedioxy)androst-4-en-3-one 1044-89-9 99.63%
    17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT.
    17,17-(Ethylenedioxy)androst-4-en-3-one
  • HY-113031
    16a-Hydroxydehydroisoandrosterone 1232-73-1 98.54%
    16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.
    16a-Hydroxydehydroisoandrosterone
Cat. No. Product Name / Synonyms Application Reactivity