H-Val-Pro-Pro-OH TFA
Based on 1 publication(s) in Google Scholar
H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2828433-08-3
- Formula: C17H26F3N3O6
- Molecular Weight:425.40
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) H-Val-Pro-Pro-OH TFA
MoreAll Angiotensin Receptor Isoforms
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Biological Activity
IC50: 9 μM (ACE)[1].
H-Val-Pro-Pro-OH (TFA), a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM[1]. H-Val-Pro-Pro-OH (TFA) could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH (TFA) also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH (TFA) further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2828433-08-3
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Appearance Solid
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Molecular Weight 425.40
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Formula C17H26F3N3O6
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Pharm
The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions. [Abstract]2024 Apr 25:655:124055. PMID: 38554741
Solvent & Solubility
H2O : 125 mg/mL (293.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (58.77 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]
[2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3507 mL | 11.7536 mL | 23.5073 mL | 58.7682 mL |
| 5 mM | 0.4701 mL | 2.3507 mL | 4.7015 mL | 11.7536 mL | |
| 10 mM | 0.2351 mL | 1.1754 mL | 2.3507 mL | 5.8768 mL | |
| 15 mM | 0.1567 mL | 0.7836 mL | 1.5672 mL | 3.9179 mL | |
| 20 mM | 0.1175 mL | 0.5877 mL | 1.1754 mL | 2.9384 mL | |
| 25 mM | 0.0940 mL | 0.4701 mL | 0.9403 mL | 2.3507 mL | |
| 30 mM | 0.0784 mL | 0.3918 mL | 0.7836 mL | 1.9589 mL | |
| 40 mM | 0.0588 mL | 0.2938 mL | 0.5877 mL | 1.4692 mL | |
| 50 mM | 0.0470 mL | 0.2351 mL | 0.4701 mL | 1.1754 mL | |
| 60 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9795 mL | |
| 80 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7346 mL | |
| 100 mM | 0.0235 mL | 0.1175 mL | 0.2351 mL | 0.5877 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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