Infection

GalNAc unconjugated/naked Xalnesiran is a non-GalNAc-conjugated Xalnesiran (HY-145638). Xalnesiran is siRNA for the study of chronic hepatitis B (HBV).

Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding PqsR proteins. Quorum sensing-IN-9 inhibits the expression of quorum sensing systems related genes lasB, rhlA and pqsA, blocks the generation of virulence factors elastase, pyocyanin and rhamnolipid. Quorum sensing-IN-9 destorys the motility of P. aeruginosa, inhibits the biofilm formation, decreasing the virulence and pathogenicity of P. aeruginosa. Quorum sensing-IN-9 exhibits anti-infectious activity in Galleria mellonella larval model.

Potassium clavulanate mixture with silicon dioxide (1:1) is a powdered mixture of 1 part Potassium clavulanate to 1 part Silicon dioxide.

SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (M^Pro) and Cathepsin L (CatL), with IC₅₀s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 14.7 nM.

Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum.

ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.

Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens.

RSV L-protein-IN-2 (Compound A) is a noncompetitive RSV polymerase inhibitor (IC₅₀: 4.5 μM). RSV L-protein-IN-2 shows antiviral activity against long RSV strains (EC₅₀: 1.3 μM).

MMV024101 shows potency against P. falciparum NF54 with an IC₅₀ value of 543 nM, which has antiplasmodial activity.

2,5-Dimethyl-3 (2H)-furanone (2,5-dimethyl-2,3-dihydrofuran-3-one) is an α,β-unsaturated 3 (2H)-furanone flavoring substance. 2,5-Dimethyl-3 (2H)-furanone does not show mutagenic activity in S. typhimurium.

Azelastine-¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Azelastine hydrochloride. Azelastine-¹³C,d₃ (hydrochloride), an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine-¹³C,d₃ (hydrochloride) can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.

Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS production to promote cancer cell apoptosis.

CUHK242 is a bacterial transcription inhibitor, with a MIC of 2 μg/mL for B. subtilis reporter strain BS2019. CUHK242 has antimicrobial activity against Staphylococcus aureus. CUHK242 can inhibit RNA synthesis in cells, thereby simultaneously reducing protein synthesis.

DZ-2640 is an orally active Carbapenem antibiotic, a prodrug of DU-6681 (HY-19247). DU-6681 exhibits antibacterial activity against a broad spectrum of gram-positive and -negative bacteria.

cCF10 is a peptide sex pheromone. cCF10 induces transfer of the conjugative plasmid pCF10 from plasmid-containing donor cells to plasmid-free recipient cells. cCF10 induces Opp system and enters bacterial cells to inhibit (p)ppGpp accumulation. cCF10 reduces persister cell generation via maintaining the metabolically active state of bacteria.

Metoprolol (tartrate) (Standard) is the analytical standard of Metoprolol (tartrate). This product is intended for research and analytical applications. Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

Prunella vulgaris extract (Spica prunellae extract) is an extract of Prunella vulgaris that can be used in anti-infective research.

Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections.

Herpes virus inhibitor 1 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. Herpes virus inhibitor 1 inhibits viral replication.

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.