Premafloxacin
Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research.
For research use only. We do not sell to patients.
- CAS No.: 143383-65-7
- Formula: C21H26FN3O4
- Molecular Weight:403.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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TOPO IV |
Premafloxacin (24-48 h) exhibits activity against wild-type S. aureus ISP794 with MIC of 0.004-0.008 μg/mL, while showing 4- to 8-fold decreased activity against various grlA and grlB mutants of these two strains with altered subunits of topoisomrase IV (MIC: 0.032-0.064 μg/mL)[1].
Premafloxacin (2-8× MIC; 48 h) fails to select for resistant single-step mutants of S. aureus ISP794 at 4 × or higher MICs, with resistant mutants only detectable at 2× MIC (mutation frequency: 6.4×10-10 to 4.0×10-7)[1].
Premafloxacin (24 h) exhibits potent in vitro activity against both Corynebacterium bovis and Corynebacterium amylocolatum strains isolated from bovine mammary glands, with MIC90s of 0.015 μg/mL[2].
Premafloxacin (24-48 h) exhibits a 2-fold decreased activity against flqB mutant, which overexpresses NorA efflux pump, indicating that it is a poor substrate for NorA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143383-65-7
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Molecular Weight 403.45
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Formula C21H26FN3O4
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SMILES
O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@]([C@@H](NC)C)(CC3)[H])C4CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ince D, et al. Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Antimicrob Agents Chemother. 2000;44(12):3344-3350. [Content Brief]
[2]. Watts JL, et al. Susceptibilities of Corynebacterium bovis and Corynebacterium amylocolatum isolates from bovine mammary glands to 15 antimicrobial agents. Antimicrob Agents Chemother. 2000;44(12):3476-3477. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Premafloxacin Related Classifications
HY-180414 Related Classifications
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