143383-65-7
Chemical Structure
Premafloxacin
- CAS No.: 143383-65-7
- Formula:C21H26FN3O4
- Molecular Weight:403.45
IUPAC Name: 1-cyclopropyl-6-fluoro-8-methoxy-7-((R)-3-((S)-1-(methylamino)ethyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: SUQUWONDIBHQOZ-NWDGAFQWSA-N
SMILES: O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@]([C@@H](NC)C)(CC3)[H])C4CC4
Biological Activity: Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research[1][2].
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Premafloxacin | Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research. | |||||||||||||||||||||
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References
- [1]. Ince D, et al. Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Antimicrob Agents Chemother. 2000;44(12):3344-3350. [Content Brief]
- [2]. Watts JL, et al. Susceptibilities of Corynebacterium bovis and Corynebacterium amylocolatum isolates from bovine mammary glands to 15 antimicrobial agents. Antimicrob Agents Chemother. 2000;44(12):3476-3477. [Content Brief]
