Candidone
Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA.
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- CAS No.: 77727-18-5
- Formule: C22H24O4
- Masse moléculaire:352.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
|
Bax |
Bcl-2 |
MMP-9 |
Caspase 3 |
Caspase 9 |
p38 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
23 μg/mL
Compound: 5
|
Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 15043430] |
Chemical Information
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CAS No. 77727-18-5
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Masse moléculaire 352.42
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Formule C22H24O4
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SMILES
COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Boonyarat C, et al. Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells. Biol Pharm Bull. 2021 Apr 1;44(4):494-500. [Content Brief]
[3]. Dehkordi MF, et al. The interaction mechanism of candidone with calf thymus DNA: A multi-spectroscopic and MD simulation study. Int J Biol Macromol. 2023 Apr 30;235:123713. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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