Candidone
Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 77727-18-5
- 分子式: C22H24O4
- 分子量:352.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
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Bax |
Bcl-2 |
MMP-9 |
Caspase 3 |
Caspase 9 |
p38 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
23 μg/mL
Compound: 5
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Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 15043430] |
化学情報
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CAS 番号 77727-18-5
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分子量 352.42
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分子式 C22H24O4
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SMILES
COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Boonyarat C, et al. Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells. Biol Pharm Bull. 2021 Apr 1;44(4):494-500. [Content Brief]
[3]. Dehkordi MF, et al. The interaction mechanism of candidone with calf thymus DNA: A multi-spectroscopic and MD simulation study. Int J Biol Macromol. 2023 Apr 30;235:123713. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Candidone 関連分類
HY-180324 関連分類
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