2. Apoptosis MAPK/ERK Pathway Metabolic Enzyme/Protease Anti-infection Cell Cycle/DNA Damage
  3. Bcl-2 Family Caspase p38 MAPK MMP Apoptosis Bacterial DNA/RNA Synthesis Survivin
  4. Candidone

Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA.

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Candidone

Candidone Chemical Structure

CAS No. : 77727-18-5

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Candidone Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Description

Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA[1][2][3].

IC50 & Target[1][2]

Bax

 

Bcl-2

 

MMP-9

 

Caspase 3

 

Caspase 9

 

p38

 

Molecular Weight

352.42

Formula

C22H24O4
CAS No.
SMILES

COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Candidone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candidone77727-18-5Bcl-2 FamilyCaspasep38 MAPKMMPApoptosisBacterialDNA/RNA SynthesisSurvivinMatrix metalloproteinasesDerris indicaDNA interactiongroove bindingapoptosischolangiocarcinomaHepG2migration inhibitionmolecular dockingMMP-9Inhibitorinhibitorinhibit

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