77727-18-5
Chemical Structure
Candidone
- CAS No.: 77727-18-5
- Formula:C22H24O4
- Molecular Weight:352.42
IUPAC Name: (S)-5,7-dimethoxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one
InChIKey: JYESOAFLKFHYHP-SFHVURJKSA-N
SMILES: COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(C(OC)=C1)C/C=C(C)\C
Biological Activity: Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA[1][2][3].
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Candidone | Candidone is a type of flavanone phenolic compound with anti-cancer and antibacterial activities. Candidone inhibits the proliferation of hepatoblastoma and cholangiocarcinoma cells and induces their apoptosis by up-regulating p21, Bax, and caspase 3/9, and down-regulating Bcl-2 and survivin. It reduces the metastatic ability of cancer cells by inhibiting the expression of phosphorylated p38 and matrix metalloproteinase MMP-9. Candidone has inhibitory effects on multidrug-resistant bacterial strains. Candidone binds to the base pairs of DNA in a groove-binding manner, thereby slightly altering the conformation of DNA. | |||||||||||||||||||||
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- [1]. Boonyarat C, et al. Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells. Biol Pharm Bull. 2021 Apr 1;44(4):494-500. [Content Brief]
- [2]. Kurasug B, et al. Antitumor effects of candidone extracted from Derris indica (Lamk) Bennet in cholangiocarcinoma cells. Tropical Journal of Pharmaceutical Research. 2018;17(7):1337-43.
- [3]. Dehkordi MF, et al. The interaction mechanism of candidone with calf thymus DNA: A multi-spectroscopic and MD simulation study. Int J Biol Macromol. 2023 Apr 30;235:123713. [Content Brief]
Keywords
