UAWJ-247
UAWJ-247 is a potent and reversible SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 0.042 μM and a Ki of 0.035 μM. UAWJ-247 can be used for the research of covid-19.
For research use only. We do not sell to patients.
- CAS No.: 1802664-84-1
- Formula: C24H28N3NaO8S
- Molecular Weight:541.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SARS-CoV-2 Mpro 0.042 μM (IC50) |
SARS-CoV-2 Mpro 0.035 μM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Vero C1008 | EC50 |
2.06 μM
Compound: 61; UAWJ247
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Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
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[PMID: 37244162] |
In Vitro
UAWJ-247 potently inhibits SARS-CoV-2 Mpro, stabilizes tag-free Mpro, binds to Mpro dimers, and forms π-stacking interactions with His41[1].
UAWJ-247 (5 days) is non-toxic to various cell lines, such as Caco-2 and Vero, with CC50s > 100 μM[1].
UAWJ-247 (3 days) inhibits SARS-CoV-2 replication in Vero E6 cells, with an EC50 of 2.06 μM in plaque assay[1].
UAWJ-247 (1.1-100 μM; 48 h) inhibits SARS-CoV-2 replication in Vero E6 cells with an EC50 of 6.81 μM in the immunofluorescence assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Vero E6 cells
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Concentration:1.1; 3.7; 11; 33; 100 μM
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Incubation Time:48 h
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Result:Inhibited SARS-CoV-2 replication with an EC50 of 6.81 μM.
Chemical Information
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CAS No. 1802664-84-1
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Molecular Weight 541.55
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Formula C24H28N3NaO8S
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SMILES
O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UAWJ-247 Related Classifications
HY-180405 Related Classifications
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