UAWJ-247
UAWJ-247 is a potent and reversible SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 0.042 μM and a Ki of 0.035 μM. UAWJ-247 can be used for the research of covid-19.
For research use only. We do not sell to patients.
- CAS No.: 1802664-84-1
- Formula: C24H28N3NaO8S
- Molecular Weight:541.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SARS-CoV-2 Mpro 0.042 μM (IC50) |
SARS-CoV-2 Mpro 0.035 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | EC50 |
2.06 μM
Compound: 61; UAWJ247
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Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay
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[PMID: 37244162] |
UAWJ-247 potently inhibits SARS-CoV-2 Mpro, stabilizes tag-free Mpro, binds to Mpro dimers, and forms π-stacking interactions with His41[1].
UAWJ-247 (5 days) is non-toxic to various cell lines, such as Caco-2 and Vero, with CC50s > 100 μM[1].
UAWJ-247 (3 days) inhibits SARS-CoV-2 replication in Vero E6 cells, with an EC50 of 2.06 μM in plaque assay[1].
UAWJ-247 (1.1-100 μM; 48 h) inhibits SARS-CoV-2 replication in Vero E6 cells with an EC50 of 6.81 μM in the immunofluorescence assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero E6 cells
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Concentration:1.1; 3.7; 11; 33; 100 μM
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Incubation Time:48 h
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Result:Inhibited SARS-CoV-2 replication with an EC50 of 6.81 μM.
Chemical Information
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CAS No. 1802664-84-1
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Molecular Weight 541.55
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Formula C24H28N3NaO8S
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SMILES
O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UAWJ-247 Related Classifications
HY-180405 Related Classifications
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