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Art. -Nr.: HY-180405

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UAWJ-247

UAWJ-247 is a potent and reversible SARS-CoV-2 main protease (Mpro) inhibitor with an IC₅₀ of 0.042 μM and a K_i of 0.035 μM. UAWJ-247 can be used for the research of covid-19.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1802664-84-1
Formel: C₂₄H₂₈N₃NaO₈S
Molecular Weight:541.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

UAWJ-247 Chemical Structure

CAS. Nr.: 1802664-84-1

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

UAWJ-247 is a potent and reversible SARS-CoV-2 main protease (Mpro) inhibitor with an IC₅₀ of 0.042 μM and a K_i of 0.035 μM. UAWJ-247 can be used for the research of covid-19^[1].

IC₅₀ & Target

^[1]

SARS-CoV-2 Mpro

0.042 μM (IC₅₀)

SARS-CoV-2 Mpro

0.035 μM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	EC₅₀	2.06 μM Compound: 61; UAWJ247	Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral replication incubated for 3 days by viral plaque assay	[PMID: 37244162]

In Vitro

UAWJ-247 potently inhibits SARS-CoV-2 Mpro, stabilizes tag-free Mpro, binds to Mpro dimers, and forms π-stacking interactions with His41^[1].
UAWJ-247 (5 days) is non-toxic to various cell lines, such as Caco-2 and Vero, with CC₅₀s > 100 μM^[1].
UAWJ-247 (3 days) inhibits SARS-CoV-2 replication in Vero E6 cells, with an EC₅₀ of 2.06 μM in plaque assay^[1].
UAWJ-247 (1.1-100 μM; 48 h) inhibits SARS-CoV-2 replication in Vero E6 cells with an EC₅₀ of 6.81 μM in the immunofluorescence assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

Vero E6 cells
Concentration:

1.1; 3.7; 11; 33; 100 μM
Incubation Time:

48 h
Result:

Inhibited SARS-CoV-2 replication with an EC₅₀ of 6.81 μM.

Chemical Information

CAS. Nr. 1802664-84-1
Molecular Weight 541.55
Formel C₂₄H₂₈N₃NaO₈S
SMILES

O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sacco MD, et al. Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L. bioRxiv [Preprint]. 2020 Jul 27:2020.07.27.223727. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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