2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123779
    RWJ-49815 193282-45-0 98%
    RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor. RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections.
    RWJ-49815
  • HY-123819
    KRH-1636 568526-77-2 98%
    KRH-1636 is a CXC chemokine receptor (CXCR) 4 antagonist. KRH-1636 can be used in HIV-1 research.
    KRH-1636
  • HY-123883
    MK-0536 865298-81-3 98%
    MK-0536 is a highly potent HIV-1 integrase inhibitor that effectively suppresses the replication of wild-type viruses. MK-0536 retains significant antiviral activity against multiple key drug-resistant mutants such as Y143R and N155H, and shows no toxicity to uninfected cells. MK-0536 selectively blocks the strand transfer reaction of integrase by chelating magnesium ions at the active site and interacting with viral DNA and enzyme residues. MK-0536 is applicable to the study of HIV infection mechanisms.
    MK-0536
  • HY-123884
    GSK-214096 716354-87-9 98%
    GSK-214096 is a selective CCR5 antagonist and an inhibitor of HIV-1 entry. GSK-214096 inhibits HIV-1 glycoprotein 120 (gp120).
    GSK-214096
  • HY-123896
    Calceolarioside A 84744-28-5 98%
    Calceolarioside A is phenylethanoid glycoside with moderate binding affinity on HIV gp41.
    Calceolarioside A
  • HY-123914
    P516-0475 1359627-33-0 98%
    P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance.
    P516-0475
  • HY-12396R
    Aminothiazole (Standard) 96-50-4 98%
    Aminothiazole (Standard) is the analytical standard of Aminothiazole. This product is intended for research and analytical applications. Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.
    Aminothiazole (Standard)
  • HY-124018
    MMV665852 4300-43-0 98%
    MMV665852 is an antischistosomal agent that inhibits worm viability in vitro. MMV665852 reduces worm burden in mice infected with Schistosoma mansoni.
    MMV665852
  • HY-12404R
    Diminazene aceturate (Standard) 908-54-3 98%
    Diminazene (aceturate) (Standard) is the analytical standard of Diminazene (aceturate). This product is intended for research and analytical applications. Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
    Diminazene aceturate (Standard)
  • HY-124052
    AZ-27 1516772-44-3 98%
    AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.
    AZ-27
  • HY-124068
    LQB-118 1219104-20-7 98%
    LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.
    LQB-118
  • HY-124078
    NIC 114773-20-5 98%
    NIC is a host invasion inhibitor. NIC can suppress host invasion by interacting with the major invasion-related protein, merozoite surface protein 1 (MSP-1). NIC prevents the invasion of Plasmodium falciparum and Plasmodium vivax into the host.
    NIC
  • HY-124093
    8-Deazahomofolic acid 111113-73-6 98%
    8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors.
    8-Deazahomofolic acid
  • HY-124106
    Resorstatin 139552-96-8 98%
    Resorstatin is a dialkylresorcinol that can be isolated from a liquid culture of Pseudomonas sp. Ki19. Resorstatin exhibits antimicrobial activity.
    Resorstatin
  • HY-124111
    10-Deoxymethymycin 36826-66-1 98%
    10-Deoxymethymycin (Antibiotic YC 17) displays antibiotic activity against Gram positive bacteria.
    10-Deoxymethymycin
  • HY-124139
    CCG 102487 353787-50-5 98%
    CCG-102487 is a streptokinase (SK) inhibitor. CCG-102487 impairs bacterial exploitation of host fibrinolysis and enhances neutrophil phagocytosis. CCG-102487 is promising for research of streptococcal infections (e.g., pharyngitis, necrotizing fasciitis).
    CCG 102487
  • HY-124184
    D715-2441 54245-10-2 98%
    D715-2441 is an influenza virus RNA polymerase inhibitor (IC50=1.7-4.4 μM). D715-2441 exhibits broad-spectrum antiviral activity against multiple influenza A strains. D715-2441 is promising for research of seasonal influenza and influenza viruses.
    D715-2441
  • HY-124195
    Antitubercular agent-57 461431-74-3 98%
    Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis.
    Antitubercular agent-57
  • HY-124224
    D4-Ribavirin 131922-28-6 98%
    D4-Ribavirin (Compound 4) is a deoxygenated ribavirin analogue. D4-Ribavirin has antiviral property in vitro against the RNA-containing bunyaviruses–Rift Valley Fever () with an IC50 of 61 μg/mL.
    D4-Ribavirin
  • HY-124262
    Saptomycin E 137714-92-2 98%
    Saptomycin E is an antitumor antibiotic.
    Saptomycin E
Cat. No. Product Name / Synonyms Application Reactivity