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Cat. No.: HY-124052

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AZ-27

AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.

For research use only. We do not sell to patients.

CAS No.: 1516772-44-3
Formula: C₃₆H₃₅N₅O₄S
Molecular Weight:633.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AZ-27 Chemical Structure

CAS No.: 1516772-44-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay	[PMID: 24211022]
HEp-2	CC₅₀	>50 μM Compound: 11f	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 24211022]
HEp-2	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]
HEp-2	EC₅₀	1 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]

Chemical Information

CAS No. 1516772-44-3
Molecular Weight 633.76
Formula C₃₆H₃₅N₅O₄S
SMILES

O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC=CN=C5N(CC6)CCC76COC7)=O)C=C4)=O)CC2)NC8CC8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Noton SL, et al. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug;89(15):7786-98. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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