LQB-118

Cat. No.: HY-124068: Data Sheet Handling Instructions
FAQs
Technical Support

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

For research use only. We do not sell to patients.

LQB-118 Chemical Structure

CAS No. : 1219104-20-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All GSK-3 Isoform Specific Products:

View All Isoforms

GSK-3 GSK-3α GSK-3β

View All MMP Isoform Specific Products:

View All Isoforms

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.21 μM Compound: 5a	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 20117936]
Daudi	IC₅₀	3.1 μM Compound: 5a	Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
HCT-8	IC₅₀	2.6 μM Compound: (+/-)-1a	Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 22000949]
HL-60	IC₅₀	1.3 μM Compound: (+/-)-1a	Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22000949]
HL-60	IC₅₀	2 μM Compound: 5a	Growth inhibition of human HL60 cells after 72 hrs by MTT assay Growth inhibition of human HL60 cells after 72 hrs by MTT assay	[PMID: 20117936]
J774	IC₅₀	12.7 μM Compound: (+/-)-1a	Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages	[PMID: 22000949]
J774	IC₅₀	18.5 μM Compound: (+/-)-1a	Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay	[PMID: 22000949]
Jurkat	IC₅₀	6.77 μM Compound: 5a	Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
K562	IC₅₀	1.67 μM Compound: (+/-)-1a	Antineoplastic activity against human K562 cells after 72 hrs by MTT assay Antineoplastic activity against human K562 cells after 72 hrs by MTT assay	[PMID: 22000949]
K562	IC₅₀	1.67 μM Compound: 5a	Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
K562-Lucena 1	IC₅₀	2.75 μM Compound: 5a	Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
LNCaP	IC₅₀	1.1 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
MDA-MB-435	IC₅₀	2.3 μM Compound: (+/-)-1a	Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 22000949]
NCI-H460	IC₅₀	12.86 μM Compound: 5a	Growth inhibition of human H460 cells after 72 hrs by MTT assay Growth inhibition of human H460 cells after 72 hrs by MTT assay	[PMID: 20117936]
PBMC	IC₅₀	> 20 μM Compound: (+/-)-1a	Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay	[PMID: 22000949]
PBMC	IC₅₀	> 20 μM Compound: 5a	Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
PC-3	IC₅₀	1.7 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
RWPE-1	IC₅₀	1.3 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
Raji	IC₅₀	3.32 μM Compound: 5a	Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
SF-295	IC₅₀	3.6 μM Compound: (+/-)-1a	Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay	[PMID: 22000949]

Molecular Weight

304.30

Formula

C₁₉H₁₂O₄

CAS No.

1219104-20-7

SMILES

O=C1C2=C(C(C3=CC=CC=C31)=O)OC[C@@]4([H])[C@]2([H])OC5=CC=CC=C45

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bernardo PS, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43(1):346-357. [Content Brief]

[2]. Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43(1):359-367. [Content Brief]

[3]. Lima ÉA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399. [Content Brief]

[4]. Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68(4):789-99. [Content Brief]

LQB-118 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQB-1181219104-20-7LQB118LQB 118ApoptosisGSK-3MMPReactive Oxygen Species (ROS)Glycogen synthase kinase-3Glycogen synthase kinase 3Matrix metalloproteinasesAKT/GSK3βMMP-9/reckapoptosisinflammationtumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *