1219104-20-7
Chemical Structure
LQB-118
- CAS No.: 1219104-20-7
- Formula:C19H12O4
- Molecular Weight:304.30
IUPAC Name: (7aS,12aS)-7a,12a-dihydro-7H-benzo[g]benzofuro[3,2-c]chromene-5,13-dione
InChIKey: BUEHOQICFGQBNY-ACJLOTCBSA-N
SMILES: O=C1C2=C(C(C3=CC=CC=C31)=O)OC[C@@]4([H])[C@]2([H])OC5=CC=CC=C45
Biological Activity:
LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases[1][2][3][4].
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LQB-118 | LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases. |
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- [1]. Bernardo PS, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43(1):346-357. [Content Brief]
- [2]. Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43(1):359-367. [Content Brief]
- [3]. Lima ÉA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399. [Content Brief]
- [4]. Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68(4):789-99. [Content Brief]
Keywords
