Infection

Cationomycin inhibits the activity of Gram-positive bacteria and mycobacterium, but has no effect on Gram-negative bacteria, yeast and fungi. The feed containing 50-100 ppm Cationomycin could effectively prevent coccidiosis of chicken.

K11002 hydrobromide is a cysteine protease inhibitor. K11002 hydrobromide forms a covalent bond with the active site cysteine residue via Michael addition. K11002 hydrobromide inhibits the growth of Trypanosoma brucei. K11002 hydrobromide can be used in the research of African human trypanosomiasis (sleeping sickness).

Pillaromycin A has anti-mycobacteria, Gram-positive bacteria and Gram-negative bacteria effects, but the effect of anti-Gram-negative bacteria is weak. Pillaromycin A also has antitumor activity.

Zinniol is a penta-substituted benzene phytotoxin that can be produced by a variety of phytopathogenic fungi. Zinniol can be detected in sunflower tissues in the early stage of infection and may be involved in the occurrence of sunflower diseases.

Tioxolone (Standard) is the analytical standard of Tioxolone. This product is intended for research and analytical applications. Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis.

PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC₅₀ of 1.0 μg/mL and a K_d of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis.

Opaviraline (GW420867X) is an anti-HIV-1 reverse transcriptase inhibitor.

Lamivudine-¹³C,¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.

Toremifene (citrate) (Standard) is the analytical standard of Toremifene (citrate). This product is intended for research and analytical applications. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively.

IMBI (compound 32) is an antibacterial agent that inhibits quorum sensing (QS) against drug-resistant pathogens. IMBI inhibits biofilm formation of Salmonella marcescens and restores or increases its susceptibility to antimicrobial drugs.

SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC₅₀ of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC₅₀ of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC₅₀ of 0.103 μM.

Valinomycin (Standard) is the analytical standard of Valinomycin (HY-N6693). This product is intended for research and analytical applications. Valinomycin is a potassium-specific ionophore, the valinomycin-K⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K⁺ gradient across the membrane, and as a result K_ills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research.

Glysperin A has anti-Gram positive bacteria and negative bacteria (including aminoglycoside antibiotic resistant bacteria) activity.

JRC-I-191 is an anti-HIV-1 agent. JRC-I-191 inhibits HIV-1 YU-2 entry into cells. JRC-I-191 does not inhibit infection of cells by amphotropic murine leukemia virus. JRC-I-191 can be used for the research of HIV-1 infection.

ω-azido-C6 Ceramide reduces the membrane potential, and exhibits antibacterial activity against Neisseria, with MIC of 2 µg/ml for N. meningitidis MC58 and N. gonorrhoeae FA1090.

Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales.

3,3'-Methylenebis[5-methyloxazolidine] is a bisoxazolidine-based hydrogen sulfide scavenger and fungicide derived from monoisopropanolamine (MIPA). 3,3'-Methylenebis[5-methyloxazolidine] exists as a mixture of structural isomers. 3,3'-Methylenebis[5-methyloxazolidine] is oil-soluble and serves as an oil-soluble alternative to hydrated hexahydrotriazine-based scavengers. 3,3'-Methylenebis[5-methyloxazolidine] can scavenge hydrogen sulfide and methanethiol via chemical reactions, and its scavenging efficiency increases after hydrolysis to MIPA-triazine in water.

Pleuromutilin conjugate T7 is a broad-spectrum antibacterial agent. Pleuromutilin conjugate T7 inhibits bacterial energy uptake, reverses drug efflux, interferes with carbohydrate metabolism, inhibits protein synthesis, disrupts biofilms, impairs cell membrane integrity, and attenuates the functions of virulence and adhesion factors. Pleuromutilin conjugate T7 can be used in studies related to Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) infections, multidrug-resistant Enterococcus faecalis infections, and Gram-negative bacterial infections.

Polyoxin H is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.

5-Amino-4-carbethoxy-1-phenylpyrazole is a pyrazole derivative that inhibits biofilm formation by Staphylococcus aureus strains without exerting significant inhibitory effects on the growth of planktonic bacteria. 5-Amino-4-carbethoxy-1-phenylpyrazole can be used in studies related to Staphylococcus aureus infections.