2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10587
    Catechin 7-O-β-D-glucopyranoside 65597-47-9 99.67%
    Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.
    Catechin 7-O-β-D-glucopyranoside
  • HY-N10634
    D-Glucosyl-β-1,1′-N-palmitoylsphingosine 74365-77-8 99.30%
    D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl (β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand with immunostimulatory activity. D-Glucosyl-β-1,1′-N-palmitoylsphingosine binds to and activates macrophage-inducible C-type lectin (Mincle). D-Glucosyl-β-1,1′-N-palmitoylsphingosine is applicable to the research of immune system diseases.
    D-Glucosyl-β-1,1′-N-palmitoylsphingosine
  • HY-N13239
    Dandelion Extract
    Dandelion Extract is a dandelion extract, and its ingredients include: Flavone. Dandelion Extract can reduce LPS-induced inflammatory responses in RAW264.7 cells by regulating cell polarization and apoptosis. Dandelion Extract can also reduce CuSO4-induced inflammatory response in zebrafish larvae..
    Dandelion Extract
  • HY-N6810R
    Thymol (Standard) 89-83-8 99.92%
    Thymol (Standard) is the analytical standard of Thymol. This product is intended for research and analytical applications. Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
    Thymol (Standard)
  • HY-P10639
    C5aR2 agonist P32 2097449-46-0 99.17%
    C5aR2 agonist P32 (Ac-RHYPYWR-OH) is a C5aR2-selective agonist. C5aR2 agonist P32 has been shown to elicit multiple immunomodulatory activities, both by down-regulating the C5aR1-mediated cell signalling, and acting in a C5aR1-independent fashion, in vitro and in vivo.
    C5aR2 agonist P32
  • HY-U00350
    CCX354 1010073-75-2 ≥99.0%
    CCX354 is an antagonist of CCR1, with anti-inflammatory activity.
    CCX354
  • HY-107784R
    Ectoine (Standard) 96702-03-3 98.66%
    Ectoine (Standard) is the analytical standard of Ectoine. This product is intended for research and analytical applications. Ectoine is a natural cell protectant, an amino acid derivate produced by bacteria living under extremely harsh environmental conditions. Ectoine serves as an osmoregulatory compatible solute, increasing the hydration of the skin surface and stabilizing lipid layers, which is useful in skincare. Ectoine demonstrates a good safety profile for the treatment of allergic rhinitis.
    Ectoine (Standard)
  • HY-113076R
    Thiamine pyrophosphate (Standard) 154-87-0 98.40%
    Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases.
    Thiamine pyrophosphate (Standard)
  • HY-172163C
    FITC-dextran sulfate (MW 500kDa)
    FITC-dextran sulfate, 500kDa is a sodium dextran sulfate labeled with FITC, with an average molecular weight of 500 kDa.
    FITC-dextran sulfate (MW 500kDa)
  • HY-B0617AR
    S-Adenosyl-L-methionine tosylate (Standard) 52248-03-0
    S-Adenosyl-L-methionine tosylate (Standard) (S-Adenosyl methionine tosylate (Standard)) is the analytical standard of S-Adenosyl-L-methionine tosylate (HY-B0617A). This product is intended for research and analytical applications. S-Adenosyl-L-methionine (S-Adenosyl methionine) tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine tosylate has the potential for, cancer, liver disease and osteoarthritis research.
    S-Adenosyl-L-methionine tosylate (Standard)
  • HY-P990238
    Anti-Human/Rat HER2 (neu) Antibody (7.16.4)
    Anti-Human/Rat HER2 (neu) Antibody (7.16.4) is an anti-human and anti-rat HER2 IgG2a monoclonal antibody. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) reduces tumor cell proliferation by inhibiting the HER2 signaling pathway. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can activate CD8+ T cells. Anti-Human/Rat HER2 (neu) Antibody (7.16.4) can be used for research on cancer such as breast cancer.
    Anti-Human/Rat HER2 (neu) Antibody (7.16.4)
  • HY-P990496
    Anti-PVRIG Antibody (COM701) 99.14%
    Anti-PVRIG Antibody (COM701) is a CHO-expressed human antibody that targets PVRIG. The predicted molecular weight (MW) of Anti-PVRIG Antibody (COM701) is 145.48 kDa. The isotype control for Anti-PVRIG Antibody (COM701) can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-PVRIG Antibody (COM701)
  • HY-P990733
    Cibotercept 2769700-97-0 ≥99.0%
    Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH.
    Cibotercept
  • HY-P990759
    Rezetamig 2795115-07-8
    Rezetamig is a human bispecific antibody that recognizes the CD3 antigen on T-lymphocytes and the CD22 antigen on mature and malignant B-lymphocytes.
    Rezetamig
  • HY-P991567
    VX5
    VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer.
    VX5
  • HY-W105505
    SAMe-1,4-Butanedisulfonate 101020-79-5 98.03%
    SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders.
    SAMe-1,4-Butanedisulfonate
  • HY-W142432
    Perfluoroundecanoic acid 2058-94-8 ≥98.0%
    Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation.
    Perfluoroundecanoic acid
  • HY-W718300
    Indole-3-pyruvic acid-d5 85163-57-1
    Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.
    Indole-3-pyruvic acid-d5
  • HY-W753791
    (±)-Perillaldehyde 2111-75-3
    (±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM.
    (±)-Perillaldehyde
  • HY-W251598S
    Bicarbonate-13C sodium 87081-58-1 99%
    Bicarbonate-13C sodium is the 13C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.
    Bicarbonate-13C sodium
Cat. No. Product Name / Synonyms Application Reactivity