Rezetamig
Based on 1 Customer Validation
Rezetamig is a human bispecific antibody that recognizes the CD3 antigen on T-lymphocytes and the CD22 antigen on mature and malignant B-lymphocytes.
For research use only. We do not sell to patients.
- Purity: 95.65%
- CAS No.: 2795115-07-8
- Molecular Weight:111.027 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
half-IGG4-kappa/VH-h-CH2-CH3
Human
CD3E & CD22
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
P07766 & P35329-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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half-G4-kappa_VH-h-CH2-CH3
ELISA, FACS, Functional assay
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Immobilized Siglec-2/CD22 Protein, Human (HEK293, His, HY-P72019) can bind Rezetamig. The EC50 for this effect is 16.16 ng/mL. -
Flow cytometric analysis of 1X106 Juakat cells with Rezetamig (HY-P990759, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2795115-07-8
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Appearance Liquid
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Molecular Weight 111.027 kDa
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Color Colorless to light yellow
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Synonyms
JNJ-75348780
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Rezetamig
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)