2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133567
    SET7-IN-DC21 2567886-53-5 98%
    SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer.
    SET7-IN-DC21
  • HY-133608
    4,6-Dichloroguaiacol 16766-31-7 98%
    4,6-Dichloroguaiacol induces biochemical and morphological changes in human peripheral blood lymphocytes in vitro.
    4,6-Dichloroguaiacol
  • HY-133727
    Terfenadine N-oxide 634901-83-0 98%
    Terfenadine N-oxide, an N-oxide derivative of Terfenadine (HY-B1193), is a histamine H1 receptor antagonist (IC50 = 2.73 μM) and an hERG potassium channel inhibitor (IC50 = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias.
    Terfenadine N-oxide
  • HY-133747
    JAK3-IN-9 1430095-30-9 98%
    JAK3-IN-9 is an orally active JAK3 inhibitor with IC50 value of 1.7 nM. JAK3-IN-9 is highly selective to the JAK3 signal path. JAK3-IN-9 is lowly toxic with high oral bioavailability, shows good anti-arthritis activity. JAK3-IN-9 can be used in autoimmune disease research.
    JAK3-IN-9
  • HY-133879
    Calcitriol lactone 81203-50-1 98%
    Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function.
    Calcitriol lactone
  • HY-133935
    Benaxibine 27661-27-4 98%
    Benaxibine is an alkaloid belonging to the quinolone family of compounds. Benaxibine has a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor and immune-enhancing effects. Benaxibine can be used for screening and research of diseases such as inflammation and tumor.
    Benaxibine
  • HY-133965
    Cinchonain IIa 85081-23-8 98%
    Cinchonain IIa is an antioxidant agent with EC50s of 6.8 μM and 26.5 μM for DPPH and PMS-NADH.
    Cinchonain IIa
  • HY-134006
    Stemoninine 69772-72-1 98%
    Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC50=5.52 μM).
    Stemoninine
  • HY-13402S
    Varespladib-d7 1360701-64-9
    Varespladib-d7 (LY315920-d7) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
    Varespladib-d7
  • HY-134045
    (-)-Anatoxin A 92142-32-0 98%
    (-)-Anatoxin A is an enantiomer of (±)-Anatoxin A (HY-N2326). (-)-Anatoxin A is a neuronal nicotinic acetylcholine receptor agonist. (-)-Anatoxin A can be used for pain and inflammation research.
    (-)-Anatoxin A
  • HY-134181
    Tremella polysaccharide, MW>1000000, cosmetic grade 9075-53-0 98%
    Tremella polysaccharide, MW>1000000, cosmetic grade, one of the fungus polysaccharides, possesses immunity enhancing capabilities. Polysaccharidase has the potential for leukopenia induced by chemotherapy and radiotherapy research.
    Tremella polysaccharide, MW>1000000, cosmetic grade
  • HY-134242
    6-T-5'-GMP disodium 74686-78-5 98%
    6-T-5'-GMP disodium is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, azathioprine (HY-B0256).
    6-T-5'-GMP disodium
  • HY-134361
    ATP-γ-S tetrasodium 88453-52-5 98%
    ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.
    ATP-γ-S tetrasodium
  • HY-134371
    IL-17 modulator 2 1449208-36-9 98%
    IL-17 modulator 2 (compound 159) is an orally active modulator of IL-17. IL-17 modulator 2 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 2 can used in study arthritis.
    IL-17 modulator 2
  • HY-134375
    cAIMP 1507367-51-2 98%
    cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L.
    cAIMP
  • HY-134440
    α,β-Methylene-ATP dilithium 104809-20-3 98%
    α,β-Methylene-ATP dilithium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system.
    α,β-Methylene-ATP dilithium
  • HY-134511
    15(S)-HpEPE 125992-60-1 98%
    15(S)-HpEPE is a product of lipoxygenase hydrolysis of unsaturated fatty acids (PUFA) and is a potential inhibitor of prostaglandin H synthase 2 (PGHS-2). 15(S)-HpEPE can downregulate the expression of PGHS-2.
    15(S)-HpEPE
  • HY-134520
    21-Deacetoxy deflazacort 13649-88-2 98%
    21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant.
    21-Deacetoxy deflazacort
  • HY-134521
    Diclofenac amide 15362-40-0 98%
    Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg).
    Diclofenac amide
  • HY-134664
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 67667-71-4 98%
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively.
    8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate
Cat. No. Product Name / Synonyms Application Reactivity