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製品番号: HY-133747

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JAK3-IN-9

JAK3-IN-9 is an orally active JAK3 inhibitor with IC₅₀ value of 1.7 nM. JAK3-IN-9 is highly selective to the JAK3 signal path. JAK3-IN-9 is lowly toxic with high oral bioavailability, shows good anti-arthritis activity. JAK3-IN-9 can be used in autoimmune disease research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1430095-30-9
分子式: C₁₇H₂₃N₅O₄S
分子量:393.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK3-IN-9 構造式

CAS 番号: 1430095-30-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

JAK3

1.7 nM (IC₅₀)

JAK アイソフォーム固有の製品をすべて表示 :

体外実験

JAK3-IN-9 (compound 11i) shows high selective inhibition of JAK3 with IC₅₀ value of 1.7 nM ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

PBMCs^[1]
Concentration:

1 μM
Incubation Time:

30 min
Result:

Showed preferential inhibition of JAK3^[1].

体内実験

JAK3-IN-9 (compound 11i) (Female Lewis rats; 3, 10 and 30 mg/kg; Oral gavage once daily for 20 days) can selectively inhibit JAK3 cytokine signaling in the primary cells^[1].
JAK3-IN-9 (Male DBA1j of 8 to 12-weeks old mice; 1mg/kg, Intravenous injection, Single administration) shows high AUC of 2104 μg/ml, extends t_1/2 to 2.56 h and good oral bioavailability of 48%^[1].
JAK3-IN-9 (30 mg/kg; Oral gavage once daily for 20 days) suppress paw swelling in a dose-dependent manner with ED₅₀ value of 10 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male DBA1j (8 to 12-weeks old) mice; Female Lewis rats^[1].
Dosage:

1, 3, 10 and 30 mg/kg
Administration:

I.V, Single administration; IG, once daily for 20 days.
Result:

Showed anti-arthritis activity in the CIA mice model^[1].

Related Protocols :

化学情報

CAS 番号 1430095-30-9
分子量 393.46
分子式 C₁₇H₂₃N₅O₄S
SMILES

CC(C)[C@@H](C)NC1=C(C(N)=O)C=NC(NC2=CC=C(OS(=O)(C)=O)C=C2)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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