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Cat. No.: HY-133727

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Terfenadine N-oxide

Terfenadine N-oxide, an N-oxide derivative of Terfenadine (HY-B1193), is a histamine H1 receptor antagonist (IC₅₀ = 2.73 μM) and an hERG potassium channel inhibitor (IC₅₀ = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias.

For research use only. We do not sell to patients.

CAS No.: 634901-83-0
Formula: C₃₂H₄₁NO₃
Molecular Weight:487.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Terfenadine N-oxide Chemical Structure

CAS No.: 634901-83-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

H₁ Receptor

2.73 μM (IC₅₀)

All Histamine Receptor Isoforms :

In Vitro

Terfenadine N-oxide (Compound Comparative Example D) shows IC₅₀ values of 2.73 and 0.698 μmM for Histamine H1 receptor and hERG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 634901-83-0
Molecular Weight 487.67
Formula C₃₂H₄₁NO₃
SMILES

[O-][N+]1(CCC(C(C2=CC=CC=C2)(C3=CC=CC=C3)O)CC1)CCCC(C4=CC=C(C(C)(C)C)C=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Robert George Boyle, et al. N-oxide-containing pharmaceutical compounds. WO2008139152A1. 2009-11-11

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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