634901-83-0
634901-83-0
Chemical Structure
Terfenadine N-oxide
- CAS No.: 634901-83-0
- Formula:C32H41NO3
- Molecular Weight:487.67
IUPAC Name: 1-(4-(4-(tert-butyl)phenyl)-4-hydroxybutyl)-4-(hydroxydiphenylmethyl)piperidine 1-oxide
InChIKey: CFDFVVYPNXXEDN-UHFFFAOYSA-N
SMILES: [O-][N+]1(CCC(C(C2=CC=CC=C2)(C3=CC=CC=C3)O)CC1)CCCC(C4=CC=C(C(C)(C)C)C=C4)O
Biological Activity: Terfenadine N-oxide, an N-oxide derivative of Terfenadine (HY-B1193), is a histamine H1 receptor antagonist (IC50 = 2.73 μM) and an hERG potassium channel inhibitor (IC50 = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias[1].
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Terfenadine N-oxide | Terfenadine N-oxide, an N-oxide derivative of Terfenadine (HY-B1193), is a histamine H1 receptor antagonist (IC50 = 2.73 μM) and an hERG potassium channel inhibitor (IC50 = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias. | |||||||||||||||||||||
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